Expression patterns of polo‐like kinase 1 in human gastric cancer

Polo‐like kinase 1 (PLK1) is centrally involved in the regulation of mitosis in normal and malignant cells. It is known that inhibition of PLK1 expression in vitro and in vivo leads to mitotic arrest, induction of apoptosis and suppression of tumor growth. In the present study, expression of PLK1 wa...

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Published in:Cancer science 2006-04, Vol.97 (4), p.271-276
Main Authors: Weichert, Wilko, Ullrich, Andrea, Schmidt, Mathias, Gekeler, Volker, Noske, Aurelia, Niesporek, Silvia, Buckendahl, Ann‐Christin, Dietel, Manfred, Denkert, Carsten
Format: Article
Language:English
Subjects:
Adenocarcinoma - enzymology
Adenocarcinoma - secondary
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - metabolism
Cell Cycle Proteins - metabolism
Gastric Mucosa - enzymology
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Humans
Lymphatic Metastasis
Middle Aged
Neoplasm Staging
Original
Polo-Like Kinase 1
Prognosis
Protein Serine-Threonine Kinases - metabolism
Proto-Oncogene Proteins - metabolism
Stomach Neoplasms - enzymology
Stomach Neoplasms - pathology
Survival Rate
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Summary:Polo‐like kinase 1 (PLK1) is centrally involved in the regulation of mitosis in normal and malignant cells. It is known that inhibition of PLK1 expression in vitro and in vivo leads to mitotic arrest, induction of apoptosis and suppression of tumor growth. In the present study, expression of PLK1 was investigated in paraffin tissue of 135 cases of gastric adenocarcinoma and in 46 corresponding lymph node metastases by immunohistochemistry. Expression data were correlated with clinicopathological parameters and patient survival. Seventy‐three (54.1%) of 135 carcinomas showed an overexpression of PLK1 compared to normal gastric mucosa. Overexpression of PLK1 correlated positively with tumor stage, nodal status and diffuse growth pattern. PLK1 expression in the primary tumor did not differ from PLK1 expression in the corresponding lymph node metastases. PLK1 expression was a significant prognostic factor in univariate but not in multivariate survival analysis. As a conclusion, upregulated PLK1 expression in gastric cancer correlates with a malignant tumor phenotype and has impact on patient prognosis. These data underscore the importance of PLK1 in gastric carcinogenesis and present a translational link for functional data into potential clinical use by defining PLK1 as an attractive protein for novel targeted chemotherapeutic approaches in gastric cancer. (Cancer Sci 2006; 97: 271 –276)
ISSN:1347-9032
1349-7006
DOI:10.1111/j.1349-7006.2006.00170.x