Decreased expression of PinX1 protein is correlated with tumor development and is a new independent poor prognostic factor in ovarian carcinoma

• Published in: Cancer science 2010-06, Vol.101 (6), p.1543-1549
• Main Authors: Cai, Mu‐Yan, Zhang, Bin, He, Wei‐Peng, Yang, Guo‐Fen, Rao, Hui‐Lan, Rao, Zhi‐Yue, Wu, Qiu‐Liang, Guan, Xin‐Yuan, Kung, Hsiang‐Fu, Zeng, Yi‐Xin, Xie, Dan
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Cell Cycle Proteins; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Immunohistochemistry; Medical sciences; Middle Aged; Neoplasms, Glandular and Epithelial - etiology; Neoplasms, Glandular and Epithelial - mortality; Neoplasms, Glandular and Epithelial - pathology; Original; Ovarian Neoplasms - etiology; Ovarian Neoplasms - mortality; Ovarian Neoplasms - pathology; Prognosis; Proportional Hazards Models; ROC Curve; Telomerase - analysis; Tumor Suppressor Proteins - analysis; Tumor Suppressor Proteins - physiology; Tumors
• ISSN: 1347-9032; 1349-7006; 1349-7006
• DOI: 10.1111/j.1349-7006.2010.01560.x

Human interacting protein X1 (PinX1) has been identified as a critical telomerase inhibitor and proposed to be a putative tumor suppressor gene. Loss of PinX1 has been found in a large variety of malignancies, but the expression status in epithelial ovarian tumors has not been investigated. In this study, immunohistochemistry for PinX1 protein was performed on a tissue microarray (TMA) of epithelial ovarian tumors (informatively containing 25 cystadenomas, 29 borderline tumors, and 157 invasive carcinomas) and 12 normal ovaries. Receiver–operator curve (ROC) analysis was used to determine cut‐off scores for tumor positivity and to evaluate patients’ survival status. The threshold for PinX1 positivity was determined to be above 60% (area under the curve = 0.856, P