High mobility group box‐1‐inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma

• Published in: Cancer science 2008-09, Vol.99 (9), p.1806-1812
• Main Authors: Sasahira, Tomonori, Kirita, Tadaaki, Oue, Naohide, Bhawal, Ujjal Kumar, Yamamoto, Kazuhiko, Fujii, Kiyomu, Ohmori, Hitoshi, Luo, Yi, Yasui, Wataru, Bosserhoff, Anja Katrin, Kuniyasu, Hiroki
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Extracellular Matrix Proteins - metabolism; Female; Gene Expression Regulation, Neoplastic; Hematologic and hematopoietic diseases; HMGB Proteins - metabolism; HMGB1 Protein - metabolism; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphangiogenesis; Lymphatic Metastasis; Male; Medical sciences; Middle Aged; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; Neoplasm Proteins; NF-kappa B - metabolism; Original; Transcription Factor RelA - metabolism; Tumors; Vascular Endothelial Growth Factor C - metabolism; Vascular Endothelial Growth Factor D - metabolism
• ISSN: 1347-9032; 1349-7006; 1349-7006
• DOI: 10.1111/j.1349-7006.2008.00894.x

Melanoma inhibitory activity (MIA) is an 11‐kDa secretory protein isolated from malignant melanoma cells that is correlated with invasion and metastasis in various human malignancies. We examined MIA expression in 62 oral squamous cell carcinomas (OSCC) by immunohistochemistry. MIA expression was significantly associated with nodal metastasis (P = 0.00018). MIA expression was also associated with expression of high mobility group box‐1 (HMGB1) (P