High mobility group box‐1‐inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma

Melanoma inhibitory activity (MIA) is an 11‐kDa secretory protein isolated from malignant melanoma cells that is correlated with invasion and metastasis in various human malignancies. We examined MIA expression in 62 oral squamous cell carcinomas (OSCC) by immunohistochemistry. MIA expression was si...

Full description

Saved in:
Bibliographic Details
Published in:Cancer science 2008-09, Vol.99 (9), p.1806-1812
Main Authors: Sasahira, Tomonori, Kirita, Tadaaki, Oue, Naohide, Bhawal, Ujjal Kumar, Yamamoto, Kazuhiko, Fujii, Kiyomu, Ohmori, Hitoshi, Luo, Yi, Yasui, Wataru, Bosserhoff, Anja Katrin, Kuniyasu, Hiroki
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Extracellular Matrix Proteins - metabolism
Female
Gene Expression Regulation, Neoplastic
Hematologic and hematopoietic diseases
HMGB Proteins - metabolism
HMGB1 Protein - metabolism
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphangiogenesis
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Mouth Neoplasms - metabolism
Mouth Neoplasms - pathology
Neoplasm Proteins
NF-kappa B - metabolism
Original
Transcription Factor RelA - metabolism
Tumors
Vascular Endothelial Growth Factor C - metabolism
Vascular Endothelial Growth Factor D - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c5864-1fd733760bd5be056b7f8ce0482a94cd0b87388141cea7ed2b3f2a05d3feb9e33
cites cdi_FETCH-LOGICAL-c5864-1fd733760bd5be056b7f8ce0482a94cd0b87388141cea7ed2b3f2a05d3feb9e33
container_end_page 1812
container_issue 9
container_start_page 1806
container_title Cancer science
container_volume 99
creator Sasahira, Tomonori
Kirita, Tadaaki
Oue, Naohide
Bhawal, Ujjal Kumar
Yamamoto, Kazuhiko
Fujii, Kiyomu
Ohmori, Hitoshi
Luo, Yi
Yasui, Wataru
Bosserhoff, Anja Katrin
Kuniyasu, Hiroki
description Melanoma inhibitory activity (MIA) is an 11‐kDa secretory protein isolated from malignant melanoma cells that is correlated with invasion and metastasis in various human malignancies. We examined MIA expression in 62 oral squamous cell carcinomas (OSCC) by immunohistochemistry. MIA expression was significantly associated with nodal metastasis (P = 0.00018). MIA expression was also associated with expression of high mobility group box‐1 (HMGB1) (P 
doi_str_mv 10.1111/j.1349-7006.2008.00894.x
format article
fullrecord <record><control><sourceid>proquest_24P</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11159509</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69607012</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5864-1fd733760bd5be056b7f8ce0482a94cd0b87388141cea7ed2b3f2a05d3feb9e33</originalsourceid><addsrcrecordid>eNqNkt2O1CAYhhujcdfVWzCc6FkrlJZCYmI2k9U12cQD9ZgApe03aWG2tLvTMy_BK_DivBLpzmTUIyUQCDzv95OXJEEEZySON9uM0EKkFcYsyzHmWVyiyPaPkvPTw-OHc5UKTPOz5FkIW4wpK0TxNDkjnBFW5uw8-XENbYcGr6GHaUHt6Ocd0n7_89t3Ehe4ejage4sG2yvnB4XAdaBh8uOClJngbpVBQCoEb0BNtkb3MHXI-Vr1UTWpEOcKuBr1y7DrlGvBt9bZ9RYc8mMEw-2sBj8HZGzfI6NGA2u258mTRvXBvjjuF8nX91dfNtfpzacPHzeXN6kpOStS0tQVpRXDui61xSXTVcONxQXPlShMjTWvKOekIMaqyta5pk2ucFnTxmphKb1I3h3i7mY92NpYN8Wq5G6EQY2L9Ark3y8OOtn6OxndKEWJRYzw-hhh9LezDZMcIKzNKGdjX5IJhitM8n-C0c9ciKqMID-AZvQhjLY5lUPwmpfIrVzdlqvbq4zLh28g91H68s92fguPvkfg1RFQwai-GZUzEE5cjpmoOF-5twfuHnq7_HcBcnP5OR7oLxX01Zc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20029975</pqid></control><display><type>article</type><title>High mobility group box‐1‐inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma</title><source>Wiley Online Library Open Access</source><creator>Sasahira, Tomonori ; Kirita, Tadaaki ; Oue, Naohide ; Bhawal, Ujjal Kumar ; Yamamoto, Kazuhiko ; Fujii, Kiyomu ; Ohmori, Hitoshi ; Luo, Yi ; Yasui, Wataru ; Bosserhoff, Anja Katrin ; Kuniyasu, Hiroki</creator><creatorcontrib>Sasahira, Tomonori ; Kirita, Tadaaki ; Oue, Naohide ; Bhawal, Ujjal Kumar ; Yamamoto, Kazuhiko ; Fujii, Kiyomu ; Ohmori, Hitoshi ; Luo, Yi ; Yasui, Wataru ; Bosserhoff, Anja Katrin ; Kuniyasu, Hiroki</creatorcontrib><description>Melanoma inhibitory activity (MIA) is an 11‐kDa secretory protein isolated from malignant melanoma cells that is correlated with invasion and metastasis in various human malignancies. We examined MIA expression in 62 oral squamous cell carcinomas (OSCC) by immunohistochemistry. MIA expression was significantly associated with nodal metastasis (P = 0.00018). MIA expression was also associated with expression of high mobility group box‐1 (HMGB1) (P &lt; 0.0001) and lymph vessel density (P &lt; 0.0001). Expression levels of MIA, HMGB1, nuclear factor kB (NFkB) p65 and HMGB1–NFkB p65 binding were significantly higher in a metastatic human OSCC cell line (HSC3) than those in a non‐metastatic OSCC cell line (HSC4). Treatment with receptor for advanced glycation end products (RAGE) antisense or small interfering RNA and human recombinant HMGB1 (hrHMGB1) did not affect MIA expression, whereas HMGB1 antisense or siRNA treatment decreased MIA expression in HSC3 cells. Then HMGB1 enhanced MIA expression as an NFkB cofactor but not as a RAGE ligand. MIA neutralization by MIA antibodies increased extracellular signal‐related kinase 1/2 phosphorylation, but decreased p38 phosphorylation and the expression of vascular epithelial growth factor (VEGF)‐C and ‐D. Treatment with p38 inihibitor decreased VEGF‐C and ‐D expression in HSC3 cells. These results suggest that MIA expression is enhanced by the interaction of intracellular HMGB1 and NFkBp65 and MIA is closely involved in tumor progression and nodal metastasis by the increments of VEGF‐C and VEGF‐D in OSCC. (Cancer Sci 2008; 99: 1806– 1812)</description><identifier>ISSN: 1347-9032</identifier><identifier>ISSN: 1349-7006</identifier><identifier>EISSN: 1349-7006</identifier><identifier>DOI: 10.1111/j.1349-7006.2008.00894.x</identifier><identifier>PMID: 18616526</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Biological and medical sciences ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Extracellular Matrix Proteins - metabolism ; Female ; Gene Expression Regulation, Neoplastic ; Hematologic and hematopoietic diseases ; HMGB Proteins - metabolism ; HMGB1 Protein - metabolism ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphangiogenesis ; Lymphatic Metastasis ; Male ; Medical sciences ; Middle Aged ; Mouth Neoplasms - metabolism ; Mouth Neoplasms - pathology ; Neoplasm Proteins ; NF-kappa B - metabolism ; Original ; Transcription Factor RelA - metabolism ; Tumors ; Vascular Endothelial Growth Factor C - metabolism ; Vascular Endothelial Growth Factor D - metabolism</subject><ispartof>Cancer science, 2008-09, Vol.99 (9), p.1806-1812</ispartof><rights>2008 Japanese Cancer Association</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5864-1fd733760bd5be056b7f8ce0482a94cd0b87388141cea7ed2b3f2a05d3feb9e33</citedby><cites>FETCH-LOGICAL-c5864-1fd733760bd5be056b7f8ce0482a94cd0b87388141cea7ed2b3f2a05d3feb9e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11159509/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11159509/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,11562,27924,27925,37013,46052,46476,53791,53793</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1349-7006.2008.00894.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=20697886$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18616526$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sasahira, Tomonori</creatorcontrib><creatorcontrib>Kirita, Tadaaki</creatorcontrib><creatorcontrib>Oue, Naohide</creatorcontrib><creatorcontrib>Bhawal, Ujjal Kumar</creatorcontrib><creatorcontrib>Yamamoto, Kazuhiko</creatorcontrib><creatorcontrib>Fujii, Kiyomu</creatorcontrib><creatorcontrib>Ohmori, Hitoshi</creatorcontrib><creatorcontrib>Luo, Yi</creatorcontrib><creatorcontrib>Yasui, Wataru</creatorcontrib><creatorcontrib>Bosserhoff, Anja Katrin</creatorcontrib><creatorcontrib>Kuniyasu, Hiroki</creatorcontrib><title>High mobility group box‐1‐inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma</title><title>Cancer science</title><addtitle>Cancer Sci</addtitle><description>Melanoma inhibitory activity (MIA) is an 11‐kDa secretory protein isolated from malignant melanoma cells that is correlated with invasion and metastasis in various human malignancies. We examined MIA expression in 62 oral squamous cell carcinomas (OSCC) by immunohistochemistry. MIA expression was significantly associated with nodal metastasis (P = 0.00018). MIA expression was also associated with expression of high mobility group box‐1 (HMGB1) (P &lt; 0.0001) and lymph vessel density (P &lt; 0.0001). Expression levels of MIA, HMGB1, nuclear factor kB (NFkB) p65 and HMGB1–NFkB p65 binding were significantly higher in a metastatic human OSCC cell line (HSC3) than those in a non‐metastatic OSCC cell line (HSC4). Treatment with receptor for advanced glycation end products (RAGE) antisense or small interfering RNA and human recombinant HMGB1 (hrHMGB1) did not affect MIA expression, whereas HMGB1 antisense or siRNA treatment decreased MIA expression in HSC3 cells. Then HMGB1 enhanced MIA expression as an NFkB cofactor but not as a RAGE ligand. MIA neutralization by MIA antibodies increased extracellular signal‐related kinase 1/2 phosphorylation, but decreased p38 phosphorylation and the expression of vascular epithelial growth factor (VEGF)‐C and ‐D. Treatment with p38 inihibitor decreased VEGF‐C and ‐D expression in HSC3 cells. These results suggest that MIA expression is enhanced by the interaction of intracellular HMGB1 and NFkBp65 and MIA is closely involved in tumor progression and nodal metastasis by the increments of VEGF‐C and VEGF‐D in OSCC. (Cancer Sci 2008; 99: 1806– 1812)</description><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematologic and hematopoietic diseases</subject><subject>HMGB Proteins - metabolism</subject><subject>HMGB1 Protein - metabolism</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphangiogenesis</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasm Proteins</subject><subject>NF-kappa B - metabolism</subject><subject>Original</subject><subject>Transcription Factor RelA - metabolism</subject><subject>Tumors</subject><subject>Vascular Endothelial Growth Factor C - metabolism</subject><subject>Vascular Endothelial Growth Factor D - metabolism</subject><issn>1347-9032</issn><issn>1349-7006</issn><issn>1349-7006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkt2O1CAYhhujcdfVWzCc6FkrlJZCYmI2k9U12cQD9ZgApe03aWG2tLvTMy_BK_DivBLpzmTUIyUQCDzv95OXJEEEZySON9uM0EKkFcYsyzHmWVyiyPaPkvPTw-OHc5UKTPOz5FkIW4wpK0TxNDkjnBFW5uw8-XENbYcGr6GHaUHt6Ocd0n7_89t3Ehe4ejage4sG2yvnB4XAdaBh8uOClJngbpVBQCoEb0BNtkb3MHXI-Vr1UTWpEOcKuBr1y7DrlGvBt9bZ9RYc8mMEw-2sBj8HZGzfI6NGA2u258mTRvXBvjjuF8nX91dfNtfpzacPHzeXN6kpOStS0tQVpRXDui61xSXTVcONxQXPlShMjTWvKOekIMaqyta5pk2ucFnTxmphKb1I3h3i7mY92NpYN8Wq5G6EQY2L9Ark3y8OOtn6OxndKEWJRYzw-hhh9LezDZMcIKzNKGdjX5IJhitM8n-C0c9ciKqMID-AZvQhjLY5lUPwmpfIrVzdlqvbq4zLh28g91H68s92fguPvkfg1RFQwai-GZUzEE5cjpmoOF-5twfuHnq7_HcBcnP5OR7oLxX01Zc</recordid><startdate>200809</startdate><enddate>200809</enddate><creator>Sasahira, Tomonori</creator><creator>Kirita, Tadaaki</creator><creator>Oue, Naohide</creator><creator>Bhawal, Ujjal Kumar</creator><creator>Yamamoto, Kazuhiko</creator><creator>Fujii, Kiyomu</creator><creator>Ohmori, Hitoshi</creator><creator>Luo, Yi</creator><creator>Yasui, Wataru</creator><creator>Bosserhoff, Anja Katrin</creator><creator>Kuniyasu, Hiroki</creator><general>Blackwell Publishing Asia</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200809</creationdate><title>High mobility group box‐1‐inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma</title><author>Sasahira, Tomonori ; Kirita, Tadaaki ; Oue, Naohide ; Bhawal, Ujjal Kumar ; Yamamoto, Kazuhiko ; Fujii, Kiyomu ; Ohmori, Hitoshi ; Luo, Yi ; Yasui, Wataru ; Bosserhoff, Anja Katrin ; Kuniyasu, Hiroki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5864-1fd733760bd5be056b7f8ce0482a94cd0b87388141cea7ed2b3f2a05d3feb9e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Extracellular Matrix Proteins - metabolism</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematologic and hematopoietic diseases</topic><topic>HMGB Proteins - metabolism</topic><topic>HMGB1 Protein - metabolism</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphangiogenesis</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasm Proteins</topic><topic>NF-kappa B - metabolism</topic><topic>Original</topic><topic>Transcription Factor RelA - metabolism</topic><topic>Tumors</topic><topic>Vascular Endothelial Growth Factor C - metabolism</topic><topic>Vascular Endothelial Growth Factor D - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sasahira, Tomonori</creatorcontrib><creatorcontrib>Kirita, Tadaaki</creatorcontrib><creatorcontrib>Oue, Naohide</creatorcontrib><creatorcontrib>Bhawal, Ujjal Kumar</creatorcontrib><creatorcontrib>Yamamoto, Kazuhiko</creatorcontrib><creatorcontrib>Fujii, Kiyomu</creatorcontrib><creatorcontrib>Ohmori, Hitoshi</creatorcontrib><creatorcontrib>Luo, Yi</creatorcontrib><creatorcontrib>Yasui, Wataru</creatorcontrib><creatorcontrib>Bosserhoff, Anja Katrin</creatorcontrib><creatorcontrib>Kuniyasu, Hiroki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Sasahira, Tomonori</au><au>Kirita, Tadaaki</au><au>Oue, Naohide</au><au>Bhawal, Ujjal Kumar</au><au>Yamamoto, Kazuhiko</au><au>Fujii, Kiyomu</au><au>Ohmori, Hitoshi</au><au>Luo, Yi</au><au>Yasui, Wataru</au><au>Bosserhoff, Anja Katrin</au><au>Kuniyasu, Hiroki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High mobility group box‐1‐inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma</atitle><jtitle>Cancer science</jtitle><addtitle>Cancer Sci</addtitle><date>2008-09</date><risdate>2008</risdate><volume>99</volume><issue>9</issue><spage>1806</spage><epage>1812</epage><pages>1806-1812</pages><issn>1347-9032</issn><issn>1349-7006</issn><eissn>1349-7006</eissn><abstract>Melanoma inhibitory activity (MIA) is an 11‐kDa secretory protein isolated from malignant melanoma cells that is correlated with invasion and metastasis in various human malignancies. We examined MIA expression in 62 oral squamous cell carcinomas (OSCC) by immunohistochemistry. MIA expression was significantly associated with nodal metastasis (P = 0.00018). MIA expression was also associated with expression of high mobility group box‐1 (HMGB1) (P &lt; 0.0001) and lymph vessel density (P &lt; 0.0001). Expression levels of MIA, HMGB1, nuclear factor kB (NFkB) p65 and HMGB1–NFkB p65 binding were significantly higher in a metastatic human OSCC cell line (HSC3) than those in a non‐metastatic OSCC cell line (HSC4). Treatment with receptor for advanced glycation end products (RAGE) antisense or small interfering RNA and human recombinant HMGB1 (hrHMGB1) did not affect MIA expression, whereas HMGB1 antisense or siRNA treatment decreased MIA expression in HSC3 cells. Then HMGB1 enhanced MIA expression as an NFkB cofactor but not as a RAGE ligand. MIA neutralization by MIA antibodies increased extracellular signal‐related kinase 1/2 phosphorylation, but decreased p38 phosphorylation and the expression of vascular epithelial growth factor (VEGF)‐C and ‐D. Treatment with p38 inihibitor decreased VEGF‐C and ‐D expression in HSC3 cells. These results suggest that MIA expression is enhanced by the interaction of intracellular HMGB1 and NFkBp65 and MIA is closely involved in tumor progression and nodal metastasis by the increments of VEGF‐C and VEGF‐D in OSCC. (Cancer Sci 2008; 99: 1806– 1812)</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>18616526</pmid><doi>10.1111/j.1349-7006.2008.00894.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier ISSN: 1347-9032
ispartof Cancer science, 2008-09, Vol.99 (9), p.1806-1812
issn 1347-9032
1349-7006
1349-7006
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11159509
source Wiley Online Library Open Access
subjects Biological and medical sciences
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Extracellular Matrix Proteins - metabolism
Female
Gene Expression Regulation, Neoplastic
Hematologic and hematopoietic diseases
HMGB Proteins - metabolism
HMGB1 Protein - metabolism
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphangiogenesis
Lymphatic Metastasis
Male
Medical sciences
Middle Aged
Mouth Neoplasms - metabolism
Mouth Neoplasms - pathology
Neoplasm Proteins
NF-kappa B - metabolism
Original
Transcription Factor RelA - metabolism
Tumors
Vascular Endothelial Growth Factor C - metabolism
Vascular Endothelial Growth Factor D - metabolism
title High mobility group box‐1‐inducible melanoma inhibitory activity is associated with nodal metastasis and lymphangiogenesis in oral squamous cell carcinoma
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T04%3A40%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_24P&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High%20mobility%20group%20box%E2%80%901%E2%80%90inducible%20melanoma%20inhibitory%20activity%20is%20associated%20with%20nodal%20metastasis%20and%20lymphangiogenesis%20in%20oral%20squamous%20cell%20carcinoma&rft.jtitle=Cancer%20science&rft.au=Sasahira,%20Tomonori&rft.date=2008-09&rft.volume=99&rft.issue=9&rft.spage=1806&rft.epage=1812&rft.pages=1806-1812&rft.issn=1347-9032&rft.eissn=1349-7006&rft_id=info:doi/10.1111/j.1349-7006.2008.00894.x&rft_dat=%3Cproquest_24P%3E69607012%3C/proquest_24P%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5864-1fd733760bd5be056b7f8ce0482a94cd0b87388141cea7ed2b3f2a05d3feb9e33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=20029975&rft_id=info:pmid/18616526&rfr_iscdi=true