Helicobacter pylori risk associated with childhood home environment

Helicobacter pylori (H. pylori) is considered to be a cause of gastric ulcer, gastric cancer and other diseases. The relationship between infection and the hygiene or housing circumstances of such patients in their childhood was explored. The study subjects were those who applied for a H. pylori ant...

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Bibliographic Details
Published in:Cancer science 2003-10, Vol.94 (10), p.914-918
Main Authors: Ueda, Mitsue, Kikuchi, Shogo, Kasugai, Tatsuzo, Shunichi, Tuuki, Miyake, Chieko
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Biological and medical sciences
Birth
Birth Order
Breast Feeding
Child
Children
Drinking water
Environment
Family Characteristics
Female
Gastric cancer
Helicobacter Infections - epidemiology
Helicobacter Infections - etiology
Helicobacter Infections - transmission
Helicobacter pylori
Helicobacter pylori - physiology
Housing
Humans
Hygiene
Infections
Male
Medical sciences
Middle Aged
Odds Ratio
Questionnaires
Retrospective Studies
Sex Factors
Surveys and Questionnaires
Toilet Facilities
Toilets
Tumors
Water Supply
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Summary:Helicobacter pylori (H. pylori) is considered to be a cause of gastric ulcer, gastric cancer and other diseases. The relationship between infection and the hygiene or housing circumstances of such patients in their childhood was explored. The study subjects were those who applied for a H. pylori antibody test, and were asked to fill out a questionnaire enclosed with a test kit, inquiring as to their hygiene and housing conditions when they were 10 years old. Of 5971 applicants, 5854 agreed to participate in the study. Associations between the six factors in the questionnaire and infection were calculated, and adjusted for sex, age and district. Drinking water, type of toilet, residential area, number of people in the house, and birth order showed significant correlations with H. pylori infection. The odds ratios (95% confidence intervals) were 0.73 (0.55–0.96) for tap water, 0.72 (0.63–0.84) for flush toilets, 0.74 (0.66–0.83) for urban location, 1.34 (1.09–1.64) for 7 or more people in the household, 1.19 (1.00–1.41) for 4th or 5th in birth order, and 1.47 (1.17–1.85) for 6th or more in birth order. No significant association with breast feeding was observed. These results suggest that infection with H. pylori may be associated with water‐related sanitary factors in childhood, and that the bacillus may be transmitted within a family.
ISSN:1347-9032
1349-7006
DOI:10.1111/j.1349-7006.2003.tb01375.x