Quasi-Podands with 1,2,3-Triazole Rings from Bile Acid Derivatives: Synthesis, and Spectroscopic and Theoretical Studies

An innovative approach to producing derivatives of bile acids has been devised, utilizing the principles of “click” chemistry. By employing intermolecular [3 + 2] cycloaddition between the newly developed acyl propiolic esters of bile acids and the azide groups of 1,3,5-tris­(azidomethyl)­benzene, a...

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Bibliographic Details
Published in:Journal of organic chemistry 2024-06, Vol.89 (11), p.7561-7572
Main Authors: Kawka, Anna, Koenig, Hanna, Nowak, Damian, Pospieszny, Tomasz
Format: Article
Language:English
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Summary:An innovative approach to producing derivatives of bile acids has been devised, utilizing the principles of “click” chemistry. By employing intermolecular [3 + 2] cycloaddition between the newly developed acyl propiolic esters of bile acids and the azide groups of 1,3,5-tris­(azidomethyl)­benzene, a novel class of quasi-podands featuring 1,2,3-triazole rings has been synthesized. Identifying and characterizing these six compounds involved comprehensive analysis through spectral techniques (1H NMR, 13C NMR, and FT-IR), mass spectrometry, and the PM5 semiempirical method. The synthesized compounds’ pharmacotherapeutic potential has been evaluated, employing the Prediction of Activity Spectra for Substances (PASS) methodology. Additionally, molecular docking was performed for all molecules.
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/acs.joc.4c00195