Linking the relationship between dietary folic acid intake and risk of osteoporosis among middle‐aged and older people: A nationwide population‐based study

Among middle‐aged and older people, balanced and nutritious diets are the foundation for maintaining bone health and preventing osteoporosis. This study is aimed at investigating the link between dietary folic acid intake and the risk of osteoporosis among middle‐aged and older people. A total of 20...

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Bibliographic Details
Published in:Food science & nutrition 2024-06, Vol.12 (6), p.4110-4121
Main Authors: Zhang, Yuan‐Wei, Hu, Yan, Wang, Si‐Cheng, Li, Zu‐Hao, Cai, Gui‐Quan, Shen, Hao, Sheng, Shi‐Hao, Chen, Xiao, Weng, Wei‐Zong, Zhang, Wen‐Cai, Chen, Yuan, Su, Jia‐Can
Format: Article
Language:English
Subjects:
Confidence intervals
Demographics
Demography
Diet
Dietary intake
Disease prevention
Folic acid
Food intake
Fractures
Health risks
Homocysteine
Medical laboratories
Middle age
middle‐aged and older people
Nutrients
Older people
Original
Osteoporosis
Population studies
Population-based studies
population‐based study
Regression analysis
Regression models
Risk
Software
Statistical analysis
Vitamin B
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Summary:Among middle‐aged and older people, balanced and nutritious diets are the foundation for maintaining bone health and preventing osteoporosis. This study is aimed at investigating the link between dietary folic acid intake and the risk of osteoporosis among middle‐aged and older people. A total of 20,686 people from the National Health and Nutritional Examination Survey (NHANES) 2007–2010 are screened and included, and 5312 people aged ≥45 years with integral data are ultimately enrolled in evaluation. Demographics and dietary intake‐related data are gathered and analyzed, and the odds ratio (OR) and 95% confidence interval (CI) of each tertile category of dietary folic acid intake and each unit increase in folic acid are assessed via multivariate logistic regression models. On this basis, the receiver operating characteristic (ROC) curve is used to identify the optimal cutoff value of dietary folic acid intake for indicating the risk of osteoporosis. Of 5312 people with a mean age of 62.4 ± 11.0 years old, a total of 513 people with osteoporosis are screened, and the dietary folic acid intake amount of the osteoporosis group is significantly lower than that of the non‐osteoporosis group (p 
ISSN:2048-7177
2048-7177
DOI:10.1002/fsn3.4070