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Integrating Spatial and Morphological Characteristics into Melanoma Prognosis: A Computational Approach

In this study, the prognostic value of cellular morphology and spatial configurations in melanoma has been examined, aiming to complement traditional prognostic indicators like mitotic activity and tumor thickness. Through a computational pipeline using machine learning and deep learning methods, we...

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Published in:	Cancers 2024-05, Vol.16 (11), p.2026
Main Authors:	Bian, Chang, Ashton, Garry, Grant, Megan, Rodriguez, Valeria Pavet, Martin, Isabel Peset, Tsakiroglou, Anna Maria, Cook, Martin, Fergie, Martin
Format:	Article
Language:	English
Subjects:	Antibodies Cancer Cell physiology Computer applications Correlation analysis Cytology Deep learning Machine learning Medical prognosis Melanoma Morphology Nuclei Oncology, Experimental Physical characteristics Prognosis Skin cancer Spatial analysis Spatial distribution Statistical models Survival analysis Tumor cells Tumors
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container_title	Cancers
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creator	Bian, Chang Ashton, Garry Grant, Megan Rodriguez, Valeria Pavet Martin, Isabel Peset Tsakiroglou, Anna Maria Cook, Martin Fergie, Martin
description	In this study, the prognostic value of cellular morphology and spatial configurations in melanoma has been examined, aiming to complement traditional prognostic indicators like mitotic activity and tumor thickness. Through a computational pipeline using machine learning and deep learning methods, we quantified nuclei sizes within different spatial regions and analyzed their prognostic significance using univariate and multivariate Cox models. Nuclei sizes in the invasive band demonstrated a significant hazard ratio (HR) of 1.1 (95% CI: 1.03, 1.18). Similarly, the nuclei sizes of tumor cells and Ki67 S100 co-positive cells in the invasive band achieved HRs of 1.07 (95% CI: 1.02, 1.13) and 1.09 (95% CI: 1.04, 1.16), respectively. Our findings reveal that nuclei sizes, particularly in the invasive band, are potentially prognostic factors. Correlation analyses further demonstrated a meaningful relationship between cellular morphology and tumor progression, notably showing that nuclei size within the invasive band correlates substantially with tumor thickness. These results suggest the potential of integrating spatial and morphological analyses into melanoma prognostication.
doi_str_mv	10.3390/cancers16112026
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subjects	Antibodies Cancer Cell physiology Computer applications Correlation analysis Cytology Deep learning Machine learning Medical prognosis Melanoma Morphology Nuclei Oncology, Experimental Physical characteristics Prognosis Skin cancer Spatial analysis Spatial distribution Statistical models Survival analysis Tumor cells Tumors
title	Integrating Spatial and Morphological Characteristics into Melanoma Prognosis: A Computational Approach
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