Comparative Bioinformatic Analysis Reveals Conserved Regions in SARS-CoV-2 Genome for RAPID Pandemic Response

In the face of the SARS-CoV-2 pandemic, characterized by the virus's rapid mutation rates, developing timely and targeted therapeutic and diagnostic interventions presents a significant challenge. This study utilizes bioinformatic analyses to pinpoint conserved genomic regions within SARS-CoV-2...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-06, Vol.25 (11), p.5764
Main Authors: Karpuj, Marcela Viviana, Shaytov, D R, Shemer-Avni, Yonat, Gideon, Michael, Frenkel, Zakharia M, Sivan, Sarit
Format: Article
Language:English
Subjects:
Analysis
Case studies
Computational Biology - methods
Conserved Sequence
COVID-19
COVID-19 - epidemiology
COVID-19 - virology
Disease transmission
Drug resistance
Ethylenediaminetetraacetic acid
Genetic research
Genome, Viral
Genomes
Genomics
Health aspects
Humans
Influenza
Middle East respiratory syndrome
Mutation
Pandemics
Pathogens
Proteins
Quarantine
Respiratory diseases
SARS-CoV-2 - genetics
SARS-CoV-2 - isolation & purification
Severe acute respiratory syndrome coronavirus 2
Viruses
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Summary:In the face of the SARS-CoV-2 pandemic, characterized by the virus's rapid mutation rates, developing timely and targeted therapeutic and diagnostic interventions presents a significant challenge. This study utilizes bioinformatic analyses to pinpoint conserved genomic regions within SARS-CoV-2, offering a strategic advantage in the fight against this and future pathogens. Our approach has enabled the creation of a diagnostic assay that is not only rapid, reliable, and cost-effective but also possesses a remarkable capacity to detect a wide array of current and prospective variants with unmatched precision. The significance of our findings lies in the demonstration that focusing on these conserved genomic sequences can significantly enhance our preparedness for and response to emerging infectious diseases. By providing a blueprint for the development of versatile diagnostic tools and therapeutics, this research paves the way for a more effective global pandemic response strategy.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25115764