4-O-Methylascochlorin Synergistically Enhances 5-Fluorouracil-Induced Apoptosis by Inhibiting the Wnt/β-Catenin Signaling Pathway in Colorectal Cancer Cells

4-O-Methyl-ascochlorin (MAC), a derivative of the prenyl-phenol antibiotic ascochlorin extracted from the fungus , shows anticarcinogenic effects on various cancer cells. 5-Fluorouracil (5-FU) is used to treat colorectal cancer (CRC); however, its efficacy must be enhanced. In this study, we investi...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2024-06, Vol.25 (11), p.5746
Main Authors: Jo, Min-Young, Jeong, Yun-Jeong, Song, Kwon-Ho, Choi, Yung Hyun, Kwon, Taeg Kyu, Chang, Young-Chae
Format: Article
Language:English
Subjects:
Antibiotics
Apoptosis
Apoptosis - drug effects
beta Catenin - genetics
beta Catenin - metabolism
Cancer
Cancer cells
Cancer therapies
Cell death
Cell Line, Tumor
Cell Proliferation - drug effects
Chemotherapy
Colorectal cancer
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Cytotoxicity
Drug resistance
Drug Resistance, Neoplasm - drug effects
Drug Synergism
Ethylenediaminetetraacetic acid
Fluorouracil
Fluorouracil - pharmacology
Humans
Medical prognosis
Morphology
Oncology, Experimental
Phenols
Phosphorylation
Proteins
RNA
TOR Serine-Threonine Kinases - metabolism
Toxicity
Wnt Signaling Pathway - drug effects
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c437t-6ec0269e94985d8a139019e373e9910089f8c6640857cedcd6f39515db0765393
container_end_page
container_issue 11
container_start_page 5746
container_title International journal of molecular sciences
container_volume 25
creator Jo, Min-Young
Jeong, Yun-Jeong
Song, Kwon-Ho
Choi, Yung Hyun
Kwon, Taeg Kyu
Chang, Young-Chae
description 4-O-Methyl-ascochlorin (MAC), a derivative of the prenyl-phenol antibiotic ascochlorin extracted from the fungus , shows anticarcinogenic effects on various cancer cells. 5-Fluorouracil (5-FU) is used to treat colorectal cancer (CRC); however, its efficacy must be enhanced. In this study, we investigated the molecular mechanisms by which MAC acts synergistically with 5-FU to inhibit cell proliferation and induce apoptosis in CRC cells. MAC enhanced the cytotoxic effects of 5-FU by suppressing the Akt/mTOR/p70S6K and Wnt/β-catenin signaling pathways. It also reduced the viability of 5-FU-resistant (5-FU-R) cells. Furthermore, expression of anti-apoptosis-related proteins and cancer stem-like cell (CSC) markers by 5-FU-R cells decreased in response to MAC. Similar to MAC, the knockdown of CTNNB1 induced apoptosis and reduced expression of mRNA encoding CRC markers in 5-FU-R cells. In summary, these results suggest that MAC and other β-catenin modulators may be useful in overcoming the 5-FU resistance of CRC cells.
doi_str_mv 10.3390/ijms25115746
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11172374</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A797898189</galeid><sourcerecordid>A797898189</sourcerecordid><originalsourceid>FETCH-LOGICAL-c437t-6ec0269e94985d8a139019e373e9910089f8c6640857cedcd6f39515db0765393</originalsourceid><addsrcrecordid>eNptks9u1DAQxiMEon_gxhlZ4sKhae3Yie0TWkUtrFRUJEAcLa_jJF557cV2QHkYXoIH4Zlw1FK2CPlga-bnb2Y-TVG8QPAcYw4vzHYXqxqhmpLmUXGMSFWVEDb08cH7qDiJcQthhauaPy2OMGMccVwdFz9IeVO-12mcrYzKq9H6YBz4ODsdBhOTUdLaGVy6UTqlI6jLKzv54KcglbHl2nWT0h1Y7f0--Wgi2Mxg7UazMcm4AaRRgy8uXfz6WbYyabdIm8FJuyQ_yDR-lzPIwdbnulolaUG7FAqg1dbGZ8WTXtqon9_dp8Xnq8tP7bvy-ubtul1dl4pgmspGK1g1XHPCWd0xibIviGtMseYcQch4z1TTEMhqmrtVXdNjXqO620Da1Jjj0-LNre5-2uwyoF0K0op9MDsZZuGlEQ8zzoxi8N8EQohWmJKs8PpOIfivk45J7ExUeQbptJ-iwJBCyhnmNKOv_kG32c7syUI1lFCCSP2XGqTVwrje58JqERUryinjDLGl8fP_UPl0emeUd7o3Of7gw9ntBxV8jEH390MiKJZ9Eof7lPGXh8bcw38WCP8GdEzHmQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3067474145</pqid></control><display><type>article</type><title>4-O-Methylascochlorin Synergistically Enhances 5-Fluorouracil-Induced Apoptosis by Inhibiting the Wnt/β-Catenin Signaling Pathway in Colorectal Cancer Cells</title><source>PubMed Central (PMC)</source><source>Publicly Available Content (ProQuest)</source><creator>Jo, Min-Young ; Jeong, Yun-Jeong ; Song, Kwon-Ho ; Choi, Yung Hyun ; Kwon, Taeg Kyu ; Chang, Young-Chae</creator><creatorcontrib>Jo, Min-Young ; Jeong, Yun-Jeong ; Song, Kwon-Ho ; Choi, Yung Hyun ; Kwon, Taeg Kyu ; Chang, Young-Chae</creatorcontrib><description>4-O-Methyl-ascochlorin (MAC), a derivative of the prenyl-phenol antibiotic ascochlorin extracted from the fungus , shows anticarcinogenic effects on various cancer cells. 5-Fluorouracil (5-FU) is used to treat colorectal cancer (CRC); however, its efficacy must be enhanced. In this study, we investigated the molecular mechanisms by which MAC acts synergistically with 5-FU to inhibit cell proliferation and induce apoptosis in CRC cells. MAC enhanced the cytotoxic effects of 5-FU by suppressing the Akt/mTOR/p70S6K and Wnt/β-catenin signaling pathways. It also reduced the viability of 5-FU-resistant (5-FU-R) cells. Furthermore, expression of anti-apoptosis-related proteins and cancer stem-like cell (CSC) markers by 5-FU-R cells decreased in response to MAC. Similar to MAC, the knockdown of CTNNB1 induced apoptosis and reduced expression of mRNA encoding CRC markers in 5-FU-R cells. In summary, these results suggest that MAC and other β-catenin modulators may be useful in overcoming the 5-FU resistance of CRC cells.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms25115746</identifier><identifier>PMID: 38891932</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antibiotics ; Apoptosis ; Apoptosis - drug effects ; beta Catenin - genetics ; beta Catenin - metabolism ; Cancer ; Cancer cells ; Cancer therapies ; Cell death ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Chemotherapy ; Colorectal cancer ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Cytotoxicity ; Drug resistance ; Drug Resistance, Neoplasm - drug effects ; Drug Synergism ; Ethylenediaminetetraacetic acid ; Fluorouracil ; Fluorouracil - pharmacology ; Humans ; Medical prognosis ; Morphology ; Oncology, Experimental ; Phenols ; Phosphorylation ; Proteins ; RNA ; TOR Serine-Threonine Kinases - metabolism ; Toxicity ; Wnt Signaling Pathway - drug effects</subject><ispartof>International journal of molecular sciences, 2024-06, Vol.25 (11), p.5746</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c437t-6ec0269e94985d8a139019e373e9910089f8c6640857cedcd6f39515db0765393</cites><orcidid>0000-0003-2667-7303 ; 0000-0003-1204-2059 ; 0009-0008-8069-7624 ; 0000-0002-1454-3124</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3067474145/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3067474145?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25730,27900,27901,36988,36989,44565,53765,53767,75095</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38891932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jo, Min-Young</creatorcontrib><creatorcontrib>Jeong, Yun-Jeong</creatorcontrib><creatorcontrib>Song, Kwon-Ho</creatorcontrib><creatorcontrib>Choi, Yung Hyun</creatorcontrib><creatorcontrib>Kwon, Taeg Kyu</creatorcontrib><creatorcontrib>Chang, Young-Chae</creatorcontrib><title>4-O-Methylascochlorin Synergistically Enhances 5-Fluorouracil-Induced Apoptosis by Inhibiting the Wnt/β-Catenin Signaling Pathway in Colorectal Cancer Cells</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>4-O-Methyl-ascochlorin (MAC), a derivative of the prenyl-phenol antibiotic ascochlorin extracted from the fungus , shows anticarcinogenic effects on various cancer cells. 5-Fluorouracil (5-FU) is used to treat colorectal cancer (CRC); however, its efficacy must be enhanced. In this study, we investigated the molecular mechanisms by which MAC acts synergistically with 5-FU to inhibit cell proliferation and induce apoptosis in CRC cells. MAC enhanced the cytotoxic effects of 5-FU by suppressing the Akt/mTOR/p70S6K and Wnt/β-catenin signaling pathways. It also reduced the viability of 5-FU-resistant (5-FU-R) cells. Furthermore, expression of anti-apoptosis-related proteins and cancer stem-like cell (CSC) markers by 5-FU-R cells decreased in response to MAC. Similar to MAC, the knockdown of CTNNB1 induced apoptosis and reduced expression of mRNA encoding CRC markers in 5-FU-R cells. In summary, these results suggest that MAC and other β-catenin modulators may be useful in overcoming the 5-FU resistance of CRC cells.</description><subject>Antibiotics</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>beta Catenin - genetics</subject><subject>beta Catenin - metabolism</subject><subject>Cancer</subject><subject>Cancer cells</subject><subject>Cancer therapies</subject><subject>Cell death</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - drug therapy</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Cytotoxicity</subject><subject>Drug resistance</subject><subject>Drug Resistance, Neoplasm - drug effects</subject><subject>Drug Synergism</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Fluorouracil</subject><subject>Fluorouracil - pharmacology</subject><subject>Humans</subject><subject>Medical prognosis</subject><subject>Morphology</subject><subject>Oncology, Experimental</subject><subject>Phenols</subject><subject>Phosphorylation</subject><subject>Proteins</subject><subject>RNA</subject><subject>TOR Serine-Threonine Kinases - metabolism</subject><subject>Toxicity</subject><subject>Wnt Signaling Pathway - drug effects</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptks9u1DAQxiMEon_gxhlZ4sKhae3Yie0TWkUtrFRUJEAcLa_jJF557cV2QHkYXoIH4Zlw1FK2CPlga-bnb2Y-TVG8QPAcYw4vzHYXqxqhmpLmUXGMSFWVEDb08cH7qDiJcQthhauaPy2OMGMccVwdFz9IeVO-12mcrYzKq9H6YBz4ODsdBhOTUdLaGVy6UTqlI6jLKzv54KcglbHl2nWT0h1Y7f0--Wgi2Mxg7UazMcm4AaRRgy8uXfz6WbYyabdIm8FJuyQ_yDR-lzPIwdbnulolaUG7FAqg1dbGZ8WTXtqon9_dp8Xnq8tP7bvy-ubtul1dl4pgmspGK1g1XHPCWd0xibIviGtMseYcQch4z1TTEMhqmrtVXdNjXqO620Da1Jjj0-LNre5-2uwyoF0K0op9MDsZZuGlEQ8zzoxi8N8EQohWmJKs8PpOIfivk45J7ExUeQbptJ-iwJBCyhnmNKOv_kG32c7syUI1lFCCSP2XGqTVwrje58JqERUryinjDLGl8fP_UPl0emeUd7o3Of7gw9ntBxV8jEH390MiKJZ9Eof7lPGXh8bcw38WCP8GdEzHmQ</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Jo, Min-Young</creator><creator>Jeong, Yun-Jeong</creator><creator>Song, Kwon-Ho</creator><creator>Choi, Yung Hyun</creator><creator>Kwon, Taeg Kyu</creator><creator>Chang, Young-Chae</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2667-7303</orcidid><orcidid>https://orcid.org/0000-0003-1204-2059</orcidid><orcidid>https://orcid.org/0009-0008-8069-7624</orcidid><orcidid>https://orcid.org/0000-0002-1454-3124</orcidid></search><sort><creationdate>20240601</creationdate><title>4-O-Methylascochlorin Synergistically Enhances 5-Fluorouracil-Induced Apoptosis by Inhibiting the Wnt/β-Catenin Signaling Pathway in Colorectal Cancer Cells</title><author>Jo, Min-Young ; Jeong, Yun-Jeong ; Song, Kwon-Ho ; Choi, Yung Hyun ; Kwon, Taeg Kyu ; Chang, Young-Chae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-6ec0269e94985d8a139019e373e9910089f8c6640857cedcd6f39515db0765393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antibiotics</topic><topic>Apoptosis</topic><topic>Apoptosis - drug effects</topic><topic>beta Catenin - genetics</topic><topic>beta Catenin - metabolism</topic><topic>Cancer</topic><topic>Cancer cells</topic><topic>Cancer therapies</topic><topic>Cell death</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - drug therapy</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Cytotoxicity</topic><topic>Drug resistance</topic><topic>Drug Resistance, Neoplasm - drug effects</topic><topic>Drug Synergism</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Fluorouracil</topic><topic>Fluorouracil - pharmacology</topic><topic>Humans</topic><topic>Medical prognosis</topic><topic>Morphology</topic><topic>Oncology, Experimental</topic><topic>Phenols</topic><topic>Phosphorylation</topic><topic>Proteins</topic><topic>RNA</topic><topic>TOR Serine-Threonine Kinases - metabolism</topic><topic>Toxicity</topic><topic>Wnt Signaling Pathway - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jo, Min-Young</creatorcontrib><creatorcontrib>Jeong, Yun-Jeong</creatorcontrib><creatorcontrib>Song, Kwon-Ho</creatorcontrib><creatorcontrib>Choi, Yung Hyun</creatorcontrib><creatorcontrib>Kwon, Taeg Kyu</creatorcontrib><creatorcontrib>Chang, Young-Chae</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest Health &amp; Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health &amp; Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jo, Min-Young</au><au>Jeong, Yun-Jeong</au><au>Song, Kwon-Ho</au><au>Choi, Yung Hyun</au><au>Kwon, Taeg Kyu</au><au>Chang, Young-Chae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>4-O-Methylascochlorin Synergistically Enhances 5-Fluorouracil-Induced Apoptosis by Inhibiting the Wnt/β-Catenin Signaling Pathway in Colorectal Cancer Cells</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>25</volume><issue>11</issue><spage>5746</spage><pages>5746-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>4-O-Methyl-ascochlorin (MAC), a derivative of the prenyl-phenol antibiotic ascochlorin extracted from the fungus , shows anticarcinogenic effects on various cancer cells. 5-Fluorouracil (5-FU) is used to treat colorectal cancer (CRC); however, its efficacy must be enhanced. In this study, we investigated the molecular mechanisms by which MAC acts synergistically with 5-FU to inhibit cell proliferation and induce apoptosis in CRC cells. MAC enhanced the cytotoxic effects of 5-FU by suppressing the Akt/mTOR/p70S6K and Wnt/β-catenin signaling pathways. It also reduced the viability of 5-FU-resistant (5-FU-R) cells. Furthermore, expression of anti-apoptosis-related proteins and cancer stem-like cell (CSC) markers by 5-FU-R cells decreased in response to MAC. Similar to MAC, the knockdown of CTNNB1 induced apoptosis and reduced expression of mRNA encoding CRC markers in 5-FU-R cells. In summary, these results suggest that MAC and other β-catenin modulators may be useful in overcoming the 5-FU resistance of CRC cells.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38891932</pmid><doi>10.3390/ijms25115746</doi><orcidid>https://orcid.org/0000-0003-2667-7303</orcidid><orcidid>https://orcid.org/0000-0003-1204-2059</orcidid><orcidid>https://orcid.org/0009-0008-8069-7624</orcidid><orcidid>https://orcid.org/0000-0002-1454-3124</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1422-0067
ispartof International journal of molecular sciences, 2024-06, Vol.25 (11), p.5746
issn 1422-0067
1661-6596
1422-0067
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11172374
source PubMed Central (PMC); Publicly Available Content (ProQuest)
subjects Antibiotics
Apoptosis
Apoptosis - drug effects
beta Catenin - genetics
beta Catenin - metabolism
Cancer
Cancer cells
Cancer therapies
Cell death
Cell Line, Tumor
Cell Proliferation - drug effects
Chemotherapy
Colorectal cancer
Colorectal Neoplasms - drug therapy
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Cytotoxicity
Drug resistance
Drug Resistance, Neoplasm - drug effects
Drug Synergism
Ethylenediaminetetraacetic acid
Fluorouracil
Fluorouracil - pharmacology
Humans
Medical prognosis
Morphology
Oncology, Experimental
Phenols
Phosphorylation
Proteins
RNA
TOR Serine-Threonine Kinases - metabolism
Toxicity
Wnt Signaling Pathway - drug effects
title 4-O-Methylascochlorin Synergistically Enhances 5-Fluorouracil-Induced Apoptosis by Inhibiting the Wnt/β-Catenin Signaling Pathway in Colorectal Cancer Cells
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-24T10%3A20%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=4-O-Methylascochlorin%20Synergistically%20Enhances%205-Fluorouracil-Induced%20Apoptosis%20by%20Inhibiting%20the%20Wnt/%CE%B2-Catenin%20Signaling%20Pathway%20in%20Colorectal%20Cancer%20Cells&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Jo,%20Min-Young&rft.date=2024-06-01&rft.volume=25&rft.issue=11&rft.spage=5746&rft.pages=5746-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms25115746&rft_dat=%3Cgale_pubme%3EA797898189%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c437t-6ec0269e94985d8a139019e373e9910089f8c6640857cedcd6f39515db0765393%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3067474145&rft_id=info:pmid/38891932&rft_galeid=A797898189&rfr_iscdi=true