From Facile One-Pot Synthesis of Semi-Degradable Amphiphilic Miktoarm Polymers to Unique Degradation Properties

We report a synthesis of well-defined A B and A B miktoarm star-shaped polymers where -dimethylaminoethyl methacrylate (DMAEMA) and various cyclic esters such as ε-caprolactone (ε-CL), lactide (LA) and glycolide (GA) were used for the synthesis. Miktopolymers were obtained by simultaneously carrying...

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Bibliographic Details
Published in:Materials 2024-06, Vol.17 (11), p.2684
Main Authors: Kupczak, Maria, Mielańczyk, Anna, Fronczyk, Tomasz, Drejka, Patryk, Ledwon, Przemyslaw, Neugebauer, Dorota
Format: Article
Language:English
Subjects:
Chemical reactions
Chemical synthesis
Chloride
Composition
Contact angle
Copolymers
Degradation
Esters
Instrument industry
Molecular weight
Phase transitions
Polyesters
Polymerization
Polymers
Ring opening polymerization
Sensors
Spectrum analysis
Temperature
Thermogravimetric analysis
Weight loss
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Summary:We report a synthesis of well-defined A B and A B miktoarm star-shaped polymers where -dimethylaminoethyl methacrylate (DMAEMA) and various cyclic esters such as ε-caprolactone (ε-CL), lactide (LA) and glycolide (GA) were used for the synthesis. Miktopolymers were obtained by simultaneously carrying out atom transfer radical polymerization (ATRP) of DMAEMA, ring-opening polymerization (ROP) of cyclic esters, and reaction between the azide group in gluconamide-based (GLBr -Az) or lactonamide-based (GLBr -Az) ATRP initiators and 4-pentyn-1-ol. The relatively low dispersity indices of the obtained miktoarm stars (Đ = 1.2-1.6) indicate that control over the polymerization processes was sustained despite almost complete monomers conversions (83-99%). The presence of salts from phosphate-buffered saline (PBS) in polymer solutions affects the phase transition, increasing cloud point temperatures (T ) values. The critical aggregation concentration (CAC) values increased with a decreasing number of average molecular weights of the hydrophobic fraction. Hydrolytic degradation studies revealed that the highest reduction of molecular weight was observed for polymers with PCL and PLGCL arm. The influence of the composition on the miktopolymers hydrophilicity was investigated via water contact angle (WCA) measurement. Thermogravimetric analysis (TGA) disclosed that the number of arms and their composition in the miktopolymer affects its weight loss under the influence of temperature.
ISSN:1996-1944
1996-1944
DOI:10.3390/ma17112684