In Vitro Investigation of the Effects of Various Reducing Agents on Dentin Treated with Hydrogen Peroxide

We assessed the effect of non-protein thiols (NPSH), reduced glutathione (GSH) and -acetylcysteine (NAC), on resin shear bond strength (SBS) to hydrogen peroxide (H O )-treated dentin, and their effects on the characteristics of dentin in comparison to ascorbic acid (AA) and sodium thiosulfate (STS)...

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Bibliographic Details
Published in:Polymers 2024-05, Vol.16 (11), p.1473
Main Authors: Alatta, Alaa, Nassar, Mohannad, Gorduysus, Mehmet, Alkhatib, Walaa, Sayed, Mahmoud
Format: Article
Language:English
Subjects:
Adhesives
Antioxidants
Ascorbic acid
Bleaching
Bond strength
Bonding strength
Composite materials
Dentin
Dentistry
Distilled water
Endodontics
Free radicals
Glutathione
Humidity
Hydrogen peroxide
Microhardness
Polymerization
Reducing agents
Resin bonding
Roughness
Sodium thiosulfate
Substrates
Teeth
Thiols
Toxicity
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Summary:We assessed the effect of non-protein thiols (NPSH), reduced glutathione (GSH) and -acetylcysteine (NAC), on resin shear bond strength (SBS) to hydrogen peroxide (H O )-treated dentin, and their effects on the characteristics of dentin in comparison to ascorbic acid (AA) and sodium thiosulfate (STS). H O -treated dentin was conditioned with 5% AA, GSH, NAC, or STS applied for 1 or 5 min. The positive control group received H O without antioxidant application, and the first negative control group received distilled water (DW). The specimens received resin bonding immediately after treatment except for the second negative control group (delayed bonding). Microhardness, roughness, and topography were studied. The SBS values of all antioxidants were statistically greater than the positive control group ( < 0.05); however, NAC and AA applied for 1 min demonstrated the highest values, which were comparable to delayed bonding. All treatments removed the smear layer except DW, H O , and STS. The negative effect of H O on resin-dentin bonding was mitigated by the application of the antioxidants; however, their efficiencies were dependent on the antioxidant type and time of application. NAC was more effective in optimizing resin bonding to bleached dentin compared to GSH at 1 min application and STS at both application times but was comparable to AA. Negligible negative effects on the substrate's roughness and microhardness were detected. The antioxidant properties of the agent and its capacity to remove the smear layer are the processes underpinning the ability of a certain antioxidant to reverse the effect of H O on bonding.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym16111473