Dicarboxylic acids counteract the metabolic effects of a Western diet by boosting energy expenditure

• Published in: The Journal of clinical investigation 2024-06, Vol.134 (12), p.1-3
• Main Authors: Castagneto-Gissey, Lidia, Bornstein, Stefan R, Mingrone, Geltrude
• Format: Article
• Language: English
• Subjects: Advisors; Amino acids; Analysis; Animals; Body fat; Carbon; Dextrose; Diabetes; Dicarboxylic Acids - pharmacology; Diet; Diet, Western; Dietary fat; Energy; Energy expenditure; Energy Metabolism - drug effects; Fatty acids; Fatty liver; Glucose; Glucose tolerance; Humans; Hyperglycemia; Hyperlipidemia; Insulin resistance; Lipoproteins; Liver; Liver diseases; Metabolic disorders; Metabolic rate; Metabolism; Mice; Musculoskeletal system; Nutrients; Obesity; Obesity - metabolism; Obesity - pathology; Oxidation; Pandemics; Steatosis; Triglycerides; Type 2 diabetes
• ISSN: 0021-9738; 1558-8238; 1558-8238
• DOI: 10.1172/JCI181978

Obesity has reached pandemic proportion not only in the West but also in other countries around the world; it is now one of the leading causes of death worldwide. A Western diet is rich in saturated fats and provides more calories than necessary, contributing to the rise of the obesity rate. It also promotes the development of liver steatosis, insulin resistance, hyperglycemia, and hyperlipidemia. In this issue of the JCI, Goetzman and colleagues describe the effects of consuming dicarboxylic acids (DAs) as an alternative source of dietary fat. The 12-carbon dicarboxylic acid (DC12) was administered to mice at 20% of their daily caloric intake for nine weeks in place of triglycerides. Notably, the change in diet increased the metabolic rate, reduced body fat, reduced liver fat, and improved glucose tolerance. These findings highlight DAs as useful energy nutrients for combatting obesity and treating various metabolic disorders.