Magnetic resonance imaging of placental intralobule structure and function in a preclinical nonhuman primate model

• Published in: Biology of reproduction 2024-03, Vol.110 (6), p.1065-1076
• Main Authors: Melbourne, Andrew, Schabel, Matthias C., David, Anna L., Roberts, Victoria H.J.
• Format: Article
• Language: English
• Subjects: fetal growth restriction; IMAGING SPECIAL ISSUE; nonhuman primate; placenta; T2 relaxation
• ISSN: 0006-3363; 1529-7268; 1529-7268
• DOI: 10.1093/biolre/ioae035

Although the central role of adequate blood flow and oxygen delivery is known, the lack of optimized imaging modalities to study placental structure has impeded our understanding of its vascular function. Magnetic resonance imaging is increasingly being applied in this field, but gaps in knowledge remain, and further methodological developments are needed. In particular, the ability to distinguish maternal from fetal placental perfusion and the understanding of how individual placental lobules are functioning are lacking. The potential clinical benefits of developing noninvasive tools for the in vivo assessment of blood flow and oxygenation, two key determinants of placental function, are tremendous. Here, we summarize a number of structural and functional magnetic resonance imaging techniques that have been developed and applied in animal models and studies of human pregnancy over the past decade. We discuss the potential applications and limitations of these approaches. Their combination provides a novel source of contrast to allow analysis of placental structure and function at the level of the lobule. We outline the physiological mechanisms of placental T2 and T2* decay and devise a model of how tissue composition affects the observed relaxation properties. We apply this modeling to longitudinal magnetic resonance imaging data obtained from a preclinical pregnant nonhuman primate model to provide initial proof-of-concept data for this methodology, which quantifies oxygen transfer and placental structure across and between lobules. This method has the potential to improve our understanding and clinical management of placental insufficiency once validation in a larger nonhuman primate cohort is complete. Summary Sentence Here we overview existing MRI data acquisition methods and demonstrate our intention to uniquely combine these capabilities with newly developed analysis parameters in a translational animal model to advance our understanding of placental vascular function. Graphical Abstract