Body composition measures as a determinant of Alpelisib related toxicity

• Published in: Breast cancer research and treatment 2024-07, Vol.206 (2), p.369-376
• Main Authors: Shachar, Eliya, Raphael, Ari, Katz, Uriel, Kessner, Rivka, Shachar, Shlomit Strulov
• Format: Article
• Language: English
• Subjects: Adipose tissue; Adult; Aged; Antineoplastic Agents - adverse effects; Antineoplastic Agents - therapeutic use; Body composition; Body Composition - drug effects; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Class I Phosphatidylinositol 3-Kinases - genetics; Computed tomography; Female; Humans; Hyperglycemia; Medicine; Medicine & Public Health; Metastases; Metastasis; Middle Aged; Muscle, Skeletal - diagnostic imaging; Muscle, Skeletal - drug effects; Muscle, Skeletal - pathology; Musculoskeletal system; Mutation; Oncology; Prognosis; Retrospective Studies; Sarcopenia; Sarcopenia - chemically induced; Sarcopenia - pathology; Skeletal muscle; Thiazoles; Toxicity; Vertebrae
• ISSN: 0167-6806; 1573-7217; 1573-7217
• DOI: 10.1007/s10549-024-07315-9

Background Body composition has emerged as an important prognostic factor in patients treated with cancer. Severe depletion of skeletal muscle, sarcopenia, has been associated with poor performance status and worse oncological outcomes. We studied patients with metastatic breast cancer receiving alpelisib, to determine if sarcopenia and additional body composition measures accounting for muscle and adiposity are associated with toxicity. Methods A retrospective observational analysis was conducted, including 38 women with metastatic breast cancer and a PIK3CA mutation, treated with alpelisib as advanced line of therapy. Sarcopenia was determined by measuring skeletal muscle cross-sectional area at the third lumbar vertebra using computerized tomography. Various body composition metrics were assessed along with drug toxicity, dose reductions, treatment discontinuation, hospitalizations, time to treatment failure and overall survival. Results Sarcopenia was observed in half of the patients (n = 19, 50%), spanning normal weight, overweight, and obese individuals. Among the body composition measures, lower skeletal muscle density (SMD) was associated with an increased risk of treatment-related hyperglycaemia (P = 0.03). Additionally, lower visceral adipose tissue (VAT) was associated with alpelisib-induced rash (P = 0.04) and hospitalizations (P = 0.04). Notably, alpelisib treatment discontinuation was not impacted by alpelisib toxicity. Conclusion Body composition measures, specifically SMD and VAT may provide an opportunity to identify patients at higher risk for severe alpelisib related hyperglycemia, and cutaneous toxicity. These findings suggest the potential use of body composition assessment to caution toxicity risk, allowing for personalized therapeutic observation and intervention.