Tumor necrosis factor‑α ‑308 G/A genetic polymorphism in patients with chronic obstructive pulmonary disease presenting with hyperactive airways

• Published in: Biomedical reports 2024-08, Vol.21 (2), p.113, Article 113
• Main Authors: Hipolito, Pia Monique D, Quilala, Peter F, Dimamay, Mark Pierre S, Liles, Veni R, Yungca, Mica Xiena, Baclig, Michael O
• Format: Article
• Language: English
• Subjects: Airway management; Asthma; Biomarkers; Chronic obstructive pulmonary disease; Comorbidity; COVID-19; COVID-19 diagnostic tests; Gene polymorphism; Genetic testing; Genotype & phenotype; Hyperactivity; Hypertension; Lung diseases; Patients; Polymorphism; Regression analysis; Smoking; Tumor necrosis factor-TNF; Tumor necrosis factor-α
• ISSN: 2049-9434; 2049-9442; 2049-9442
• DOI: 10.3892/br.2024.1802

Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death worldwide. COPD is often diagnosed late in the disease leading to a delay in management. Notably, tumor necrosis factor-α (TNF-α) polymorphisms may serve an important role in the development of COPD. A single-center, case-control study was conducted to determine the presence of the TNF-α -308 G/A polymorphism among patients diagnosed with COPD presenting with hyperactive airways, patients without COPD presenting with hyperactive airways, and normal study participants without pulmonary comorbidities. Three genotypes: G/G (94%; 157/167), G/A (5%; 9/167) and A/A (1%; 1/167) were detected by quantitative PCR. The present study showed that the presence of the TNF-α -308 G/A polymorphism reduced the odds of having hyperactive airways with COPD by 29.3% and hyperactive airways without COPD by 26.3%. Multinomial logistic regression analysis showed that having the TNF-α -308 G/A polymorphism did not significantly reduce the odds of having hyperactive airways with COPD and without COPD compared to those with the G/G genotype. In conclusion, the presence of the TNF-α -308 G/A gene polymorphism showed no significant association with patients with COPD with or without hyperactive airways. The presence of the TNF-α -308 G/A polymorphism instead had a weak association with the reduction in the development of COPD regardless of the presence or absence of airway hyperactivity.