Exploring miRNA Profiles in Colon Cancer: A Focus on miR101-3p, miR106a-5p, and miR326

Early diagnosis and prognosis of cancer progression through biomarker profiling are crucial in managing colon cancer patients. Our research aimed to investigate the expression of miR-101-3p, miR-106a-5p, and miR-326 in tumor and adjacent healthy tissues of colon cancer patients and determine their p...

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Bibliographic Details
Published in:Cancers 2024-06, Vol.16 (12), p.2285
Main Authors: Tâlvan, Constantin-Dan, Tâlvan, Elena-Teodora, Mohor, Călin Ilie, Budișan, Liviuța, Grecu, Valentin, Mihalache, Manuela, Zănoagă, Oana, Chira, Sergiu, Berindan-Neagoe, Ioana, Cristea, Victor, Mohor, Cosmin Ioan
Format: Article
Language:English
Subjects:
Apoptosis
Biomarkers
Cancer
Cancer therapies
Cell growth
Colon cancer
Colorectal cancer
Comparative analysis
Development and progression
Diagnosis
Disease management
Endometrial cancer
Insulin resistance
Medical prognosis
Metastasis
MicroRNA
MicroRNAs
miRNA
Mortality
Oncology, Experimental
Patients
Prognosis
Radiation therapy
Software
Statistical analysis
Tumor staging
Tumorigenesis
Citations: Items that this one cites
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Summary:Early diagnosis and prognosis of cancer progression through biomarker profiling are crucial in managing colon cancer patients. Our research aimed to investigate the expression of miR-101-3p, miR-106a-5p, and miR-326 in tumor and adjacent healthy tissues of colon cancer patients and determine their potential diagnostic utility. This study included 40 patients divided into four groups according to the TNM staging classification. MiRNA expression was analyzed using qRT-PCR. The results showed that miR-101-3p, miR-106a-5p, and miR-326 are overexpressed in adjacent healthy tissues but decrease in advanced cancer stages. MiR-106a-5p and miR-326 are strongly correlated with colon cancer severity. These findings suggest that miRNA profiling could be useful for early diagnosis and prognosis in colon cancer management.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers16122285