Atypical Presentations of Hydroxychloroquine Retinopathy: A Case Series Study

Hydroxychloroquine retinopathy, traditionally characterized by parafoveal or pericentral outer retinal damage, is explored for atypical presentations in Asian patients. This challenges conventional beliefs regarding onset, retinopathy pattern, and associated visual field defects. Ninety-five patient...

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Bibliographic Details
Published in:Journal of clinical medicine 2024-06, Vol.13 (12), p.3411
Main Authors: Lee, Jung Min, Kwon, Hyeon Yoon, Ahn, Seong Joon
Format: Article
Language:English
Subjects:
Automation
Causes of
Complications and side effects
Demographic aspects
Development and progression
Diagnosis
Disease
Dosage and administration
Hydroxychloroquine
Kidney diseases
Ophthalmology
Photoreceptors
Retina
Retinal diseases
Risk factors
Toxicity
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Summary:Hydroxychloroquine retinopathy, traditionally characterized by parafoveal or pericentral outer retinal damage, is explored for atypical presentations in Asian patients. This challenges conventional beliefs regarding onset, retinopathy pattern, and associated visual field defects. Ninety-five patients diagnosed with hydroxychloroquine retinopathy at Hanyang University Hospital underwent screening from January 2010 to December 2023. Swept-source optical coherence tomography (SS-OCT), ultra-widefield fundus autofluorescence (UWF-FAF), and automated visual fields (VF) were employed for detailed structural and functional evaluations. Multifocal electroretinography was performed in selected cases requiring additional objective evidence of retinal toxicity. Among 95 patients, 14 (14.7%) exhibited atypical presentations, including very early onset (n = 1), (far) peripheral-dominant damages (n = 4), perivascular involvement (n = 1), bitemporal hemianopsia due to nasal extensive lesions (n = 1), unilateral involvement (n = 2), and asymmetric involvement in retinopathy pattern or severity between the eyes (n = 7). These findings underscore the importance of utilizing expanded imaging techniques, such as ultra-widefield FAF imaging, to identify atypical presentations of retinal involvement. Screening physicians should consider these atypical presentations to ensure timely diagnosis and appropriate management in patients undergoing hydroxychloroquine treatment.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13123411