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Therapeutic effects of mitoquinol during an acute heat stress challenge in growing barrows

Study objectives were to determine the effects of mitoquinol (MitoQ, a mitochondrial-targeted antioxidant) on biomarkers of metabolism and inflammation during acute heat stress (HS). Crossbred barrows [n=32; 59.0±5.6 kg body weight (BW)] were blocked by BW and randomly assigned to 1 of 4 environment...

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Published in:Journal of animal science 2024-06, Vol.102
Main Authors: Mayorga, Edith J, Horst, Erin A, Goetz, Brady M, Rodriguez-Jimenez, Sonia, Abeyta, Megan A, Al-Qaisi, Mohmmad, Rhoads, Robert P, Selsby, Joshua T, Baumgard, Lance H
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Language:English
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Summary:Study objectives were to determine the effects of mitoquinol (MitoQ, a mitochondrial-targeted antioxidant) on biomarkers of metabolism and inflammation during acute heat stress (HS). Crossbred barrows [n=32; 59.0±5.6 kg body weight (BW)] were blocked by BW and randomly assigned to 1 of 4 environmental-therapeutic treatments: 1) thermoneutral (TN) control (n=8; TNCon), 2) TN and MitoQ (n=8; TNMitoQ), 3) HS control (n=8; HSCon), or 4) HS and MitoQ (n=8; HSMitoQ). Pigs were acclimated for 6 d to individual pens before study initiation. The trial consisted of two experimental periods (P). During P1 (2 d), pigs were fed ad libitum and housed in TN conditions (20.6±0.8°C). During P2 (24 h), HSCon and HSMitoQ pigs were exposed to continuous HS (35.2±0.2°C), while TNCon and TNMitoQ remained in TN conditions. MitoQ (40 mg/d) was orally administered twice daily (0700 and 1800 h) during P1 and P2. Pigs exposed to HS had increased rectal temperature, skin temperature, and respiration rate (+1.5°C, +6.8°C, and +101 breaths/min, respectively; P
ISSN:0021-8812
1525-3163
1525-3163
DOI:10.1093/jas/skae161