Predictors of autosomal dominant polycystic kidney disease progression: a Brazilian single-center cohort

Abstract Introduction: Identifying risk factors for autosomal dominant polycystic kidney disease (ADPKD) progression is important. However, studies that have evaluated this subject using a Brazilian sample is sparce. Therefore, the aim of this study was to identify risk factors for renal outcomes an...

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Bibliographic Details
Published in:Brazilian Journal of Nephrology 2024-01, Vol.46 (3)
Main Authors: Nishimoto, Igor Hitoshi, Santos, Andrey Gonçalves, Bianchini, Júlia Mandelbaun, Santos, Luiz Gustavo Brenneisen, Martini, Maria Carolina Rodrigues, Silva, Vanessa dos Santos, Martin, Luis Cuadrado
Format: Article
Language:English
Subjects:
Mortality
Original
Polycystic Kidney, Autosomal Dominant
Rate
Renal Insufficiency
Risk Factors
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Summary:Abstract Introduction: Identifying risk factors for autosomal dominant polycystic kidney disease (ADPKD) progression is important. However, studies that have evaluated this subject using a Brazilian sample is sparce. Therefore, the aim of this study was to identify risk factors for renal outcomes and death in a Brazilian cohort of ADPKD patients. Methods: Patients had the first medical appointment between January 2002 and December 2014, and were followed up until December 2019. Associations between clinical and laboratory variables with the primary outcome (sustained decrease of at least 57% in the eGFR from baseline, need for dialysis or renal transplantation) and the secondary outcome (death from any cause) were analyzed using a multiple Cox regression model. Among 80 ADPKD patients, those under 18 years, with glomerular filtration rate
ISSN:0101-2800
2175-8239
DOI:10.1590/2175-8239-jbn-2023-0040en