The comparison of the quality of selected brands of antibiotics in Tanzania sourced from different geographical regions

• Published in: Journal of antimicrobial chemotherapy 2024-07, Vol.79 (7), p.1619-1627
• Main Authors: Mwalwisi, Yonah Hebron, Fimbo, Adam Mitangu, Hoellein, Ludwig, Nandonde, Moses, Sambu, Gerald, Ahmed, Babuali, Juma, Abdalla, Augustine, Siya, Shewiyo, Danstan Hipolite, Kaale, Eliangiringa Amos, Holzgrabe, Ulrike
• Format: Article
• Language: English
• Subjects: Amoxicillin - analysis; Amoxicillin - chemistry; Amoxicillin - standards; Anti-Bacterial Agents - analysis; Ceftriaxone - analysis; Ceftriaxone - chemistry; Ciprofloxacin - analysis; Humans; Original Research; Quality Control; Tablets; Tanzania
• ISSN: 0305-7453; 1460-2091; 1460-2091
• DOI: 10.1093/jac/dkae155

Abstract Objectives The quality of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets was evaluated to determine whether there is any difference in quality when comparing the country of origin. This was undertaken because it has been claimed that antibiotics manufactured in Europe are of superior quality to those originating from Africa or Asia. Methods Samples of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets were collected from three randomly selected wholesale pharmacies in each city, namely Arusha, Dar es Salaam and Mwanza, Tanzania. The collected samples of collected brands were subjected to quality control testing as per their respective pharmacopoeial monographs. Amoxil 250 mg capsules (Glaxo Wellcome, Mayenne, France), Rocephin (Roche, Switzerland) and Cipro-Denk 500 (Allphamed Pharbil Arzneimittel GmbH, Gottingen, Germany) were used as reference brands for the other generic brands of amoxicillin, ceftriaxone and ciprofloxacin, respectively. Results A total of 31 brands (10 different brands of amoxicillin capsules, 9 of ceftriaxone sodium injections, and 12 of ciprofloxacin tablets) were collected from the targeted regions and subjected to quality control testing. All samples of collected brands complied with the requirements of their respective pharmacopoeial monographs. Conclusions There was no significant difference in quality between brands of amoxicillin capsules, ceftriaxone for injection, and ciprofloxacin tablets manufactured in Africa and Asia against those manufactured in Europe in terms of compliance with the respective pharmacopoeial monographs.