Evaluation of Five Prognostic Scores in Patients Receiving Chemoradiation for Primary Glioblastoma Multiforme

Prognostic factors can facilitate treatment personalization in patients with glioblastoma multiforme (GBM). This study investigated different Glasgow prognostic scores (GPS) and the LabBM score in patients with GBM receiving chemoradiation following resection or biopsy. Four GPS versions, LabBM scor...

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Bibliographic Details
Published in:In vivo (Athens) 2024-07, Vol.38 (4), p.1806-1813
Main Authors: Zemskova, Oksana, Yu, Nathan Y, Löser, Anastassia, Leppert, Jan, Rades, Dirk
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Brain Neoplasms - mortality
Brain Neoplasms - pathology
Brain Neoplasms - therapy
Chemoradiotherapy - methods
Female
Glioblastoma - mortality
Glioblastoma - pathology
Glioblastoma - therapy
Humans
Male
Middle Aged
Prognosis
Retrospective Studies
Treatment Outcome
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Summary:Prognostic factors can facilitate treatment personalization in patients with glioblastoma multiforme (GBM). This study investigated different Glasgow prognostic scores (GPS) and the LabBM score in patients with GBM receiving chemoradiation following resection or biopsy. Four GPS versions, LabBM score, and 10 other factors were retrospectively investigated for progression-free survival (PFS) and overall survival (OS) in 86 patients. GPS versions included original GPS (oGPS), modified GPS (mGPS), high-sensitivity mGPS (HS-mGPS), and high-sensitivity oGPS (HS-oGPS). On multivariate analysis, higher oGPS was significantly associated with worse OS (p=0.006). On univariate analyses, trends were found for associations between higher mGPS and worse OS (p=0.098) and between higher LabBM scores and worse PFS (p=0.059). The oGPS was an independent predictor of OS in patients receiving chemoradiation for GBM and can help personalizing the treatment for these patients. The LabBM score may be useful for predicting PFS.
ISSN:0258-851X
1791-7549
1791-7549
DOI:10.21873/invivo.13632