Myocarditis in anti-synthetase syndrome: clinical features and diagnostic modalities

Abstract Objectives Myocarditis is an overlooked manifestation of anti-synthetase syndrome (ASS). Our study describes the clinical and instrumental features of ASS myocarditis and evaluates the performance of cardiac MRI (CMRI) with mapping techniques in assisting diagnosis of ASS myocarditis. Metho...

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Published in:Rheumatology (Oxford, England) England), 2024-07, Vol.63 (7), p.1902-1910
Main Authors: De Luca, Giacomo, Campochiaro, Corrado, Palmisano, Anna, Bruno, Elisa, Vignale, Davide, Peretto, Giovanni, Sala, Simone, Ferlito, Arianna, Cilona, Maria Bernardette, Esposito, Antonio, Matucci-Cerinic, Marco, Dagna, Lorenzo
Format: Article
Language:English
Subjects:
Aged
Brain natriuretic peptide
Clinical Science
Female
Fever
Gadolinium
Heart diseases
Humans
Magnetic Resonance Imaging - methods
Male
Mapping
Middle Aged
Myocarditis
Myocarditis - diagnosis
Myocarditis - diagnostic imaging
Myositis - complications
Myositis - diagnosis
Natriuretic Peptide, Brain - blood
Peptide Fragments - blood
Phenotypes
Retrospective Studies
Statistical analysis
Troponin
Troponin T
Troponin T - blood
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Summary:Abstract Objectives Myocarditis is an overlooked manifestation of anti-synthetase syndrome (ASS). Our study describes the clinical and instrumental features of ASS myocarditis and evaluates the performance of cardiac MRI (CMRI) with mapping techniques in assisting diagnosis of ASS myocarditis. Methods Data from patients with ASS were retrospectively analysed. CMRI data for patients diagnosed with myocarditis, including late gadolinium enhancement (LGE), T2 ratio, T1 mapping, extracellular volume (ECV) and T2 mapping, were reviewed. Myocarditis was defined by the presence of symptoms and/or signs suggestive for heart involvement, including increased high-sensitive troponin T (hs-TnT) and/or N-terminal pro-brain natriuretic peptide (NT-proBNP), and at least an instrumental abnormality. The clinical features of patients with ASS with and without myocarditis were compared. A P-value of
ISSN:1462-0324
1462-0332
1462-0332
DOI:10.1093/rheumatology/kead541