Secondary Hirata Syndrome in a Neonate: Practical Approach and Management

Abstract Hirata disease, also known as insulin autoimmune syndrome (IAS), is a rare cause of hypoglycemia, due to the presence of insulin autoantibodies (IAA) in the circulating blood. These antibodies are immunoglobulin G (IgG), making placental transfer to the fetus possible. To our knowledge, no...

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Bibliographic Details
Published in:JCEM case reports 2024-07, Vol.2 (7), p.luae109
Main Authors: Perri, Alessandro, Fattore, Simona, Sbordone, Annamaria, Viti, Luca, Pitocco, Dario, Vento, Giovanni
Format: Article
Language:English
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Case Report
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Summary:Abstract Hirata disease, also known as insulin autoimmune syndrome (IAS), is a rare cause of hypoglycemia, due to the presence of insulin autoantibodies (IAA) in the circulating blood. These antibodies are immunoglobulin G (IgG), making placental transfer to the fetus possible. To our knowledge, no reports of IAS have been previously described in the neonatal population. We present a case report of hypoglycemia due to a secondary IAS in a neonate and discuss the management and treatment of the disease.
ISSN:2755-1520
2755-1520
DOI:10.1210/jcemcr/luae109