Invasive Breast Cancer of No Special Type With Osteoclast-Like Giant Cells: A Cytological Clue Providing the Final Diagnosis for Histology

Breast cancer associated with osteoclast-like giant cells (OGCs) refers to a morphological pattern of invasive breast carcinoma of non-special type. Their presence is sometimes subtle, but OGCs can be appreciated both histologically and immunohistochemically. The origin of OGCs as well as their impl...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-04, Vol.16 (4), p.e58518
Main Authors: Veekmans, Tristan, Weynand, Birgit, Floris, Giuseppe
Format: Article
Language:English
Subjects:
Anatomy
Biopsy
Breast cancer
Cellular biology
Cytokeratin
Diabetes
Estrogens
Gene amplification
Granulomas
Growth factors
Histology
Infections
Inflammation
Lymphatic system
Mammography
Medical diagnosis
Oncology
Pathology
Phosphatase
Stains & staining
Tuberculosis
Tumors
Ultrasonic imaging
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Summary:Breast cancer associated with osteoclast-like giant cells (OGCs) refers to a morphological pattern of invasive breast carcinoma of non-special type. Their presence is sometimes subtle, but OGCs can be appreciated both histologically and immunohistochemically. The origin of OGCs as well as their implication for prognosis remain debated. We describe the case of a 65-year-old woman, wherein the presence of OGCs in the fine-needle aspiration cytology of a metastatic axillary lymph node suggested the final diagnosis on histology. The differential diagnosis is broad, and here we provide evidence for strict cytological-histological correlation when dealing with unusual breast lesions.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.58518