In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization

Older adults who are hospitalized for COVID-19 are at risk of delirium. Little is known about the association of in-hospital delirium with functional and cognitive outcomes among older adults who have survived a COVID-19 hospitalization. To evaluate the association of delirium with functional disabi...

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Bibliographic Details
Published in:JAMA network open 2024-07, Vol.7 (7), p.e2419640
Main Authors: Kaushik, Ramya, McAvay, Gail J, Murphy, Terrence E, Acampora, Denise, Araujo, Katy, Charpentier, Peter, Chattopadhyay, Sumon, Geda, Mary, Gill, Thomas M, Kaminski, Tamar A, Lee, Seohyuk, Li, Judy, Cohen, Andrew B, Hajduk, Alexandra M, Ferrante, Lauren E
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Cognitive ability
Cognitive Dysfunction - epidemiology
Cognitive Dysfunction - etiology
Cohort analysis
COVID-19
COVID-19 - complications
COVID-19 - epidemiology
COVID-19 - psychology
Delirium
Delirium - epidemiology
Delirium - etiology
Female
Geriatrics
Hospitalization
Hospitalization - statistics & numerical data
Humans
Male
Middle Aged
Older people
Online Only
Original Investigation
Prospective Studies
SARS-CoV-2
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Summary:Older adults who are hospitalized for COVID-19 are at risk of delirium. Little is known about the association of in-hospital delirium with functional and cognitive outcomes among older adults who have survived a COVID-19 hospitalization. To evaluate the association of delirium with functional disability and cognitive impairment over the 6 months after discharge among older adults hospitalized with COVID-19. This prospective cohort study involved patients aged 60 years or older who were hospitalized with COVID-19 between June 18, 2020, and June 30, 2021, at 5 hospitals in a major tertiary care system in the US. Follow-up occurred through January 11, 2022. Data analysis was performed from December 2022 to February 2024. Delirium during the COVID-19 hospitalization was assessed using the Chart-based Delirium Identification Instrument (CHART-DEL) and CHART-DEL-ICU. Primary outcomes were disability in 15 functional activities and the presence of cognitive impairment (defined as Montreal Cognitive Assessment score
ISSN:2574-3805
2574-3805
DOI:10.1001/jamanetworkopen.2024.19640