Artificial light at night affects the daily profile of pulse pressure and protein expression in the thoracic aorta of rats

Artificial light at night (ALAN) disrupts 24-h variability of blood pressure, but the molecular mechanisms underlying these effects are unknown. Therefore, we analysed the daily variability of pulse pressure, the maximum value of acceleration rate of aortic pressure (dP/dt (max) ) measured by teleme...

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Bibliographic Details
Published in:Hypertension research 2024-07, Vol.47 (7), p.1897-1907
Main Authors: Mauer Sutovska, Hana, Obermajer, Viktor, Zeman, Michal, Molcan, Lubos
Format: Article
Language:English
Subjects:
Animals
Aorta, Thoracic - metabolism
Blood Pressure - physiology
Calcium-Binding Proteins - metabolism
Circadian Rhythm - physiology
Extracellular Matrix Proteins - metabolism
Geriatrics/Gerontology
Health Promotion and Disease Prevention
Internal Medicine
Light
Male
Medicine
Medicine & Public Health
Obstetrics/Perinatology/Midwifery
Public Health
Rats
Rats, Sprague-Dawley
Receptor, Angiotensin, Type 1 - metabolism
Transforming Growth Factor beta1 - metabolism
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Summary:Artificial light at night (ALAN) disrupts 24-h variability of blood pressure, but the molecular mechanisms underlying these effects are unknown. Therefore, we analysed the daily variability of pulse pressure, the maximum value of acceleration rate of aortic pressure (dP/dt (max) ) measured by telemetry and protein expression in the thoracic aorta of normotensive male rats exposed to ALAN (1–2 lx) for 3 weeks. Daily, 24-h variability of pulse pressure and dP/dt (max) was observed during a regular light/dark regimen with higher values during the dark compared to the light phase of the day. ALAN suppressed 24-h variability and enhanced ultradian (
ISSN:0916-9636
1348-4214
1348-4214
DOI:10.1038/s41440-024-01685-9