Loading…
Artificial light at night affects the daily profile of pulse pressure and protein expression in the thoracic aorta of rats
Artificial light at night (ALAN) disrupts 24-h variability of blood pressure, but the molecular mechanisms underlying these effects are unknown. Therefore, we analysed the daily variability of pulse pressure, the maximum value of acceleration rate of aortic pressure (dP/dt (max) ) measured by teleme...
Saved in:
| Published in: | Hypertension research 2024-07, Vol.47 (7), p.1897-1907 |
|---|---|
| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c398t-8846b2ec812dcf1c0cd7553c1f9b906c522b5e886479e36649a89f92e44717243 |
| container_end_page | 1907 |
| container_issue | 7 |
| container_start_page | 1897 |
| container_title | Hypertension research |
| container_volume | 47 |
| creator | Mauer Sutovska, Hana Obermajer, Viktor Zeman, Michal Molcan, Lubos |
| description | Artificial light at night (ALAN) disrupts 24-h variability of blood pressure, but the molecular mechanisms underlying these effects are unknown. Therefore, we analysed the daily variability of pulse pressure, the maximum value of acceleration rate of aortic pressure (dP/dt
(max)
) measured by telemetry and protein expression in the thoracic aorta of normotensive male rats exposed to ALAN (1–2 lx) for 3 weeks. Daily, 24-h variability of pulse pressure and dP/dt
(max)
was observed during a regular light/dark regimen with higher values during the dark compared to the light phase of the day. ALAN suppressed 24-h variability and enhanced ultradian ( |
| doi_str_mv | 10.1038/s41440-024-01685-9 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11224016</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3047945808</sourcerecordid><originalsourceid>FETCH-LOGICAL-c398t-8846b2ec812dcf1c0cd7553c1f9b906c522b5e886479e36649a89f92e44717243</originalsourceid><addsrcrecordid>eNp9UUtPXCEUJqaNjo8_0EXDspurvC4Dq8aYqk1M3Ng1YbiHGcwdmAK3qf76Ml5r2o0r4HyPczgfQp8oOaeEq4siqBCkI0x0hErVd_oALSgXqhOMig9oQTSVnZZcHqHjUh4JYarX9BAdcSWl6IleoOfLXIMPLtgRj2G9qdhWHOeL9-BqwXUDeLBhfMK7nHwYASePd9NYoBWglCkDtnHYoxVCxPD7pRxSxO21V9dNytYFh23K1e7l2dZyij5621zOXs8T9OP628PVbXd3f_P96vKuc1yr2ikl5IqBU5QNzlNH3LDse-6o1ytNpOsZW_WglBRLDbz9S1ulvWYgxJIumeAn6Ovsu5tWWxgcxJrtaHY5bG1-MskG8z8Sw8as0y9DKWOibbY5fHl1yOnnBKWabSgOxtFGSFMxnLTeoldENSqbqS6nUjL4tz6UmH1qZk7NtNTMS2pGN9Hnfyd8k_yNqRH4TCgNimvI5jFNObatvWf7BwBYpRA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3047945808</pqid></control><display><type>article</type><title>Artificial light at night affects the daily profile of pulse pressure and protein expression in the thoracic aorta of rats</title><source>Nexis UK</source><source>Springer Link</source><creator>Mauer Sutovska, Hana ; Obermajer, Viktor ; Zeman, Michal ; Molcan, Lubos</creator><creatorcontrib>Mauer Sutovska, Hana ; Obermajer, Viktor ; Zeman, Michal ; Molcan, Lubos</creatorcontrib><description>Artificial light at night (ALAN) disrupts 24-h variability of blood pressure, but the molecular mechanisms underlying these effects are unknown. Therefore, we analysed the daily variability of pulse pressure, the maximum value of acceleration rate of aortic pressure (dP/dt
(max)
) measured by telemetry and protein expression in the thoracic aorta of normotensive male rats exposed to ALAN (1–2 lx) for 3 weeks. Daily, 24-h variability of pulse pressure and dP/dt
(max)
was observed during a regular light/dark regimen with higher values during the dark compared to the light phase of the day. ALAN suppressed 24-h variability and enhanced ultradian (<12-h) periods of pulse pressure and dP/dt
(max)
in duration-dependent manners. From beat-to-beat blood pressure variability, ALAN decreased low-frequency bands (a sympathetic marker) and had minimal effects on high-frequency bands. At the molecular level, ALAN decreased angiotensin II receptor type 1 expression and reduced 24-h variability. ALAN caused the appearance of 12-h oscillations in transforming growth factor β1 and fibulin 4. Expression of sarco/endoplasmic reticulum Ca
2+
-ATPase type 2 was increased in the middle of the light and dark phase of the day, and ALAN did not affect its daily and 12-h variability. In conclusion, ALAN suppressed 24-h variability of pulse pressure and dP/dt
(max)
, decreased the power of low-frequency bands and differentially affected the expression of specific proteins in the rat thoracic aorta. Suppressed 24-h oscillations by ALAN underline the pulsatility of individual endocrine axes with different periods, disrupting the cardiovascular control of central blood pressure.</description><identifier>ISSN: 0916-9636</identifier><identifier>ISSN: 1348-4214</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/s41440-024-01685-9</identifier><identifier>PMID: 38664509</identifier><language>eng</language><publisher>Singapore: Springer Nature Singapore</publisher><subject>Animals ; Aorta, Thoracic - metabolism ; Blood Pressure - physiology ; Calcium-Binding Proteins - metabolism ; Circadian Rhythm - physiology ; Extracellular Matrix Proteins - metabolism ; Geriatrics/Gerontology ; Health Promotion and Disease Prevention ; Internal Medicine ; Light ; Male ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Public Health ; Rats ; Rats, Sprague-Dawley ; Receptor, Angiotensin, Type 1 - metabolism ; Transforming Growth Factor beta1 - metabolism</subject><ispartof>Hypertension research, 2024-07, Vol.47 (7), p.1897-1907</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c398t-8846b2ec812dcf1c0cd7553c1f9b906c522b5e886479e36649a89f92e44717243</cites><orcidid>0000-0003-2797-0149 ; 0000-0002-8161-5888 ; 0000-0002-2712-6805</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38664509$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mauer Sutovska, Hana</creatorcontrib><creatorcontrib>Obermajer, Viktor</creatorcontrib><creatorcontrib>Zeman, Michal</creatorcontrib><creatorcontrib>Molcan, Lubos</creatorcontrib><title>Artificial light at night affects the daily profile of pulse pressure and protein expression in the thoracic aorta of rats</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><addtitle>Hypertens Res</addtitle><description>Artificial light at night (ALAN) disrupts 24-h variability of blood pressure, but the molecular mechanisms underlying these effects are unknown. Therefore, we analysed the daily variability of pulse pressure, the maximum value of acceleration rate of aortic pressure (dP/dt
(max)
) measured by telemetry and protein expression in the thoracic aorta of normotensive male rats exposed to ALAN (1–2 lx) for 3 weeks. Daily, 24-h variability of pulse pressure and dP/dt
(max)
was observed during a regular light/dark regimen with higher values during the dark compared to the light phase of the day. ALAN suppressed 24-h variability and enhanced ultradian (<12-h) periods of pulse pressure and dP/dt
(max)
in duration-dependent manners. From beat-to-beat blood pressure variability, ALAN decreased low-frequency bands (a sympathetic marker) and had minimal effects on high-frequency bands. At the molecular level, ALAN decreased angiotensin II receptor type 1 expression and reduced 24-h variability. ALAN caused the appearance of 12-h oscillations in transforming growth factor β1 and fibulin 4. Expression of sarco/endoplasmic reticulum Ca
2+
-ATPase type 2 was increased in the middle of the light and dark phase of the day, and ALAN did not affect its daily and 12-h variability. In conclusion, ALAN suppressed 24-h variability of pulse pressure and dP/dt
(max)
, decreased the power of low-frequency bands and differentially affected the expression of specific proteins in the rat thoracic aorta. Suppressed 24-h oscillations by ALAN underline the pulsatility of individual endocrine axes with different periods, disrupting the cardiovascular control of central blood pressure.</description><subject>Animals</subject><subject>Aorta, Thoracic - metabolism</subject><subject>Blood Pressure - physiology</subject><subject>Calcium-Binding Proteins - metabolism</subject><subject>Circadian Rhythm - physiology</subject><subject>Extracellular Matrix Proteins - metabolism</subject><subject>Geriatrics/Gerontology</subject><subject>Health Promotion and Disease Prevention</subject><subject>Internal Medicine</subject><subject>Light</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Public Health</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptor, Angiotensin, Type 1 - metabolism</subject><subject>Transforming Growth Factor beta1 - metabolism</subject><issn>0916-9636</issn><issn>1348-4214</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9UUtPXCEUJqaNjo8_0EXDspurvC4Dq8aYqk1M3Ng1YbiHGcwdmAK3qf76Ml5r2o0r4HyPczgfQp8oOaeEq4siqBCkI0x0hErVd_oALSgXqhOMig9oQTSVnZZcHqHjUh4JYarX9BAdcSWl6IleoOfLXIMPLtgRj2G9qdhWHOeL9-BqwXUDeLBhfMK7nHwYASePd9NYoBWglCkDtnHYoxVCxPD7pRxSxO21V9dNytYFh23K1e7l2dZyij5621zOXs8T9OP628PVbXd3f_P96vKuc1yr2ikl5IqBU5QNzlNH3LDse-6o1ytNpOsZW_WglBRLDbz9S1ulvWYgxJIumeAn6Ovsu5tWWxgcxJrtaHY5bG1-MskG8z8Sw8as0y9DKWOibbY5fHl1yOnnBKWabSgOxtFGSFMxnLTeoldENSqbqS6nUjL4tz6UmH1qZk7NtNTMS2pGN9Hnfyd8k_yNqRH4TCgNimvI5jFNObatvWf7BwBYpRA</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Mauer Sutovska, Hana</creator><creator>Obermajer, Viktor</creator><creator>Zeman, Michal</creator><creator>Molcan, Lubos</creator><general>Springer Nature Singapore</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2797-0149</orcidid><orcidid>https://orcid.org/0000-0002-8161-5888</orcidid><orcidid>https://orcid.org/0000-0002-2712-6805</orcidid></search><sort><creationdate>20240701</creationdate><title>Artificial light at night affects the daily profile of pulse pressure and protein expression in the thoracic aorta of rats</title><author>Mauer Sutovska, Hana ; Obermajer, Viktor ; Zeman, Michal ; Molcan, Lubos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-8846b2ec812dcf1c0cd7553c1f9b906c522b5e886479e36649a89f92e44717243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Aorta, Thoracic - metabolism</topic><topic>Blood Pressure - physiology</topic><topic>Calcium-Binding Proteins - metabolism</topic><topic>Circadian Rhythm - physiology</topic><topic>Extracellular Matrix Proteins - metabolism</topic><topic>Geriatrics/Gerontology</topic><topic>Health Promotion and Disease Prevention</topic><topic>Internal Medicine</topic><topic>Light</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Public Health</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptor, Angiotensin, Type 1 - metabolism</topic><topic>Transforming Growth Factor beta1 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mauer Sutovska, Hana</creatorcontrib><creatorcontrib>Obermajer, Viktor</creatorcontrib><creatorcontrib>Zeman, Michal</creatorcontrib><creatorcontrib>Molcan, Lubos</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mauer Sutovska, Hana</au><au>Obermajer, Viktor</au><au>Zeman, Michal</au><au>Molcan, Lubos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Artificial light at night affects the daily profile of pulse pressure and protein expression in the thoracic aorta of rats</atitle><jtitle>Hypertension research</jtitle><stitle>Hypertens Res</stitle><addtitle>Hypertens Res</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>47</volume><issue>7</issue><spage>1897</spage><epage>1907</epage><pages>1897-1907</pages><issn>0916-9636</issn><issn>1348-4214</issn><eissn>1348-4214</eissn><abstract>Artificial light at night (ALAN) disrupts 24-h variability of blood pressure, but the molecular mechanisms underlying these effects are unknown. Therefore, we analysed the daily variability of pulse pressure, the maximum value of acceleration rate of aortic pressure (dP/dt
(max)
) measured by telemetry and protein expression in the thoracic aorta of normotensive male rats exposed to ALAN (1–2 lx) for 3 weeks. Daily, 24-h variability of pulse pressure and dP/dt
(max)
was observed during a regular light/dark regimen with higher values during the dark compared to the light phase of the day. ALAN suppressed 24-h variability and enhanced ultradian (<12-h) periods of pulse pressure and dP/dt
(max)
in duration-dependent manners. From beat-to-beat blood pressure variability, ALAN decreased low-frequency bands (a sympathetic marker) and had minimal effects on high-frequency bands. At the molecular level, ALAN decreased angiotensin II receptor type 1 expression and reduced 24-h variability. ALAN caused the appearance of 12-h oscillations in transforming growth factor β1 and fibulin 4. Expression of sarco/endoplasmic reticulum Ca
2+
-ATPase type 2 was increased in the middle of the light and dark phase of the day, and ALAN did not affect its daily and 12-h variability. In conclusion, ALAN suppressed 24-h variability of pulse pressure and dP/dt
(max)
, decreased the power of low-frequency bands and differentially affected the expression of specific proteins in the rat thoracic aorta. Suppressed 24-h oscillations by ALAN underline the pulsatility of individual endocrine axes with different periods, disrupting the cardiovascular control of central blood pressure.</abstract><cop>Singapore</cop><pub>Springer Nature Singapore</pub><pmid>38664509</pmid><doi>10.1038/s41440-024-01685-9</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-2797-0149</orcidid><orcidid>https://orcid.org/0000-0002-8161-5888</orcidid><orcidid>https://orcid.org/0000-0002-2712-6805</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-9636 |
| ispartof | Hypertension research, 2024-07, Vol.47 (7), p.1897-1907 |
| issn | 0916-9636 1348-4214 1348-4214 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11224016 |
| source | Nexis UK; Springer Link |
| subjects | Animals Aorta, Thoracic - metabolism Blood Pressure - physiology Calcium-Binding Proteins - metabolism Circadian Rhythm - physiology Extracellular Matrix Proteins - metabolism Geriatrics/Gerontology Health Promotion and Disease Prevention Internal Medicine Light Male Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Public Health Rats Rats, Sprague-Dawley Receptor, Angiotensin, Type 1 - metabolism Transforming Growth Factor beta1 - metabolism |
| title | Artificial light at night affects the daily profile of pulse pressure and protein expression in the thoracic aorta of rats |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-30T22%3A59%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Artificial%20light%20at%20night%20affects%20the%20daily%20profile%20of%20pulse%20pressure%20and%20protein%20expression%20in%20the%20thoracic%20aorta%20of%20rats&rft.jtitle=Hypertension%20research&rft.au=Mauer%20Sutovska,%20Hana&rft.date=2024-07-01&rft.volume=47&rft.issue=7&rft.spage=1897&rft.epage=1907&rft.pages=1897-1907&rft.issn=0916-9636&rft.eissn=1348-4214&rft_id=info:doi/10.1038/s41440-024-01685-9&rft_dat=%3Cproquest_pubme%3E3047945808%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c398t-8846b2ec812dcf1c0cd7553c1f9b906c522b5e886479e36649a89f92e44717243%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3047945808&rft_id=info:pmid/38664509&rfr_iscdi=true |