Effect of PI3K/AKT/mTOR signaling pathway-based clustered nursing care combined with papaverine injection on vascular inflammation and vascular crisis after replantation of severed fingers

• Published in: Molecular and cellular biochemistry 2024-06, Vol.479 (6), p.1525-1534
• Main Authors: Wang, Na, Xiao, Haijing, Lu, Hongyan, Chen, Kai, Zhang, Shuhong, Liu, Fei, Zhang, Ning, Zhang, Haijing, Chen, Siyu, Xu, Xiaoli
• Format: Article
• Language: English
• Subjects: 1-Phosphatidylinositol 3-kinase; Adult; AKT protein; Amputation; Biochemistry; Biomedical and Life Sciences; Blood flow; Cancer Research; Cardiology; Clustering; Constipation; Crises; Cytokines; Enzyme-linked immunosorbent assay; Female; Finger Injuries - surgery; Fingers - blood supply; Flow resistance; Flow velocity; Humans; Inflammation; Injection; Interleukin 1; Interleukin 10; Interleukins; Kinases; Life Sciences; Male; Medical Biochemistry; Medical personnel; Middle Aged; Nurses; Nursing; Nursing care; Pain; Papaverine - administration & dosage; Papaverine - pharmacology; Patient satisfaction; Patients; Phosphatidylinositol 3-Kinases - metabolism; Proteins; Proto-Oncogene Proteins c-akt - metabolism; Rapamycin; Replantation; Side effects; Signal transduction; Signal Transduction - drug effects; Statistical analysis; Survival; TOR protein; TOR Serine-Threonine Kinases - metabolism; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Vasculitis
• ISSN: 0300-8177; 1573-4919; 1573-4919
• DOI: 10.1007/s11010-023-04796-y

This research aimed to investigate the effect of PI3K (phosphatidylinositol 3-kinase)/AKT (protein kinase B)/mTOR (mammalian target protein of rapamycin) signaling pathway-based clustering care combined with papaverine injection on vascular inflammation and vascular crisis after finger amputation and replantation. 100 patients admitted in General Hospital of Ningxia Medical University from April 2022 to December 2022 for replantation of severed fingers were selected and divided into a control group ( n  = 50) and an observation group ( n  = 50) using the randomized grouping principle. The control group received a papaverine injection and general nursing care, the observation group received a papaverine injection and clustered care. The pain score; constipation incidence; replantation finger survival rate; physician, nurse, and patient satisfaction; serum inflammatory factors; vascular crisis parameters; and occurrence of adverse reactions were compared between the two patient groups. Enzyme-linked immunosorbent assay was performed to detect PI3K, AKT, and mTOR protein concentrations in the venous blood of the two groups, and statistical analysis of the data was performed. On postoperative day 7, the pain score and incidence of constipation in the observation group were lower than those in the control group ( P