Review: The Role of Dual-Energy Computed Tomography in Detecting Monosodium Urate Deposits in Vascular Tissues

• Published in: Current rheumatology reports 2024-08, Vol.26 (8), p.302-310
• Main Authors: Held, Julia, Haschka, David, Lacaita, Pietro G., Feuchtner, Gudrun M., Klotz, Werner, Stofferin, Hannes, Duftner, Christina, Weiss, Günter, Klauser, Andrea S.
• Format: Article
• Language: English
• Subjects: Cardiovascular Diseases - diagnostic imaging; Gout - diagnostic imaging; Humans; Hyperuricemia - diagnostic imaging; Medicine; Medicine & Public Health; Review; Rheumatology; Tomography, X-Ray Computed - methods; Topical Collection on Crystal Arthritis; Uric Acid - analysis
• ISSN: 1523-3774; 1534-6307; 1534-6307
• DOI: 10.1007/s11926-024-01151-y

Purpose of Review To highlight novel findings in the detection of monosodium urate deposits in vessels using dual energy computed tomography, and to discuss the potential clinical implications for gout and hyperuricemia patients. Recent Findings Gout is an independent risk factor for cardiovascular disease. However, classical risk calculators do not take into account these hazards, and parameters to identify patients at risk are lacking. Monosodium urate measured by dual energy computed tomography is a well-established technology for the detection and quantification of monosodium urate deposits in peripheral joints and tendons. Recent findings also suggest its applicability to identify vascular urate deposits. Summary Dual energy computed tomography is a promising tool for detection of cardiovascular monosodium urate deposits in gout patients, to better delineate individuals at increased risk for cardiovascular disease.