Outbreak of Ralstonia pickettii associated with contamination of saline products distributed internationally, the United Kingdom, 2024

We describe an outbreak of in the United Kingdom, with isolates genetically indistinguishable from a 2023 Australian outbreak linked to internationally distributed saline solutions. Confirmed cases (n = 3) had bacteraemia, clinically relevant infection, indwelling venous lines and frequent healthcar...

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Bibliographic Details
Published in:Euro surveillance : bulletin européen sur les maladies transmissibles 2024-07, Vol.29 (27)
Main Authors: Saunders, Mike, Weaver, Amy, Stretch, Rebecca, Jeyaratnam, D, Mirfenderesky, Mariyam, Elliott, David, Patterson, Charlotte, Williams, David, Kenna, Dervla Td, Turton, Jack, Osman, Karen L, Turton, Jane F, Brown, Colin S, Elston, Jwt
Format: Article
Language:English
Subjects:
Australia - epidemiology
Bacteremia - epidemiology
Bacteremia - microbiology
Disease Outbreaks
Drug Contamination
Gram-Negative Bacterial Infections - epidemiology
Gram-Negative Bacterial Infections - microbiology
Humans
Male
Ralstonia pickettii - genetics
Ralstonia pickettii - isolation & purification
Rapid Communication
Saline Solution
United Kingdom - epidemiology
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Summary:We describe an outbreak of in the United Kingdom, with isolates genetically indistinguishable from a 2023 Australian outbreak linked to internationally distributed saline solutions. Confirmed cases (n = 3) had bacteraemia, clinically relevant infection, indwelling venous lines and frequent healthcare contact. Multi-stakeholder intervention was required including product recall and risk communications. We recommend a low threshold for investigating clusters of species and similar opportunistic pathogens, considering contaminated product sources. Effective mitigation requires multi-agency partnership and international collaboration.
ISSN:1560-7917
1025-496X
1560-7917
DOI:10.2807/1560-7917.ES.2024.29.27.2400384