Exploring Marchiafava-Bignami Disease: A Rare Presentation in a Young Pregnant Female

Marchiafava-Bignami disease (MBD) is uncommon and typically linked with persistent alcohol consumption; nevertheless, instances have been reported in non-alcoholic individuals with nutritional deficiencies. Depending on the severity, this condition may manifest as acute, subacute, or chronic neurolo...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-06, Vol.16 (6), p.e61701
Main Authors: Kadam, Abhinav, Toshniwal, Saket S, Kinkar, Jiwan, Kumar, Sunil, Acharya, Sourya
Format: Article
Language:English
Subjects:
Abdomen
Alcoholism
Blood
Coma
Convulsions & seizures
Disease
Etiology
Fatalities
Females
Fetuses
Hemoglobin
HIV
Hospitals
Human immunodeficiency virus
Internal Medicine
Laboratories
Magnetic resonance imaging
Malnutrition
Neurology
Obstetrics/Gynecology
Patients
Pregnancy
Uterus
Vitamin B
Vomiting
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Description
Summary:Marchiafava-Bignami disease (MBD) is uncommon and typically linked with persistent alcohol consumption; nevertheless, instances have been reported in non-alcoholic individuals with nutritional deficiencies. Depending on the severity, this condition may manifest as acute, subacute, or chronic neurological signs and symptoms, ranging from moderate dysarthria or mild disorientation to coma and death. We report a case of a 30-year-old, 14-week pregnant female who presented with complaints of persistent vomiting and loss of appetite. She was found to have achalasia cardia on upper GI endoscopy. Later, she developed confusion, irrelevant talks and her speech was incomprehensible. An MRI of the brain was done which showed features likely that of MBD. She was started high dose intravenous thiamine to which she responded brilliantly.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.61701