Initial results of investigator initiated international database on catheter directed therapy of acute pulmonary embolism

• Published in: Cardiology journal 2024, Vol.31 (3), p.390-397
• Main Authors: Jermakow, Mateusz T, Obradovic, Slobodan, Salinas, Pablo, Roik, Marek, Dzudovic, Boris, Sekulic, Igor, Macaya, Fernando, Paredes-Vazquez, Jose, Velázquez Martín, Maite, Maneiro Melón, Nicolás Manuel, Nedeljkov, Djordje, Matijasevic, Jovan, Łabyk, Andrzej, Krakowian, Marcin, Stępniewski, Jakub, Araszkiewicz, Aleksander, Pruszczyk, Piotr
• Format: Article
• Language: English
• Subjects: Acute Disease; Aged; Catheters; Databases, Factual; Female; Hospital Mortality; Humans; Interventional Cardiology; Male; Middle Aged; Mortality; Pulmonary Embolism - mortality; Pulmonary Embolism - therapy; Pulmonary embolisms; Registries; Retrospective Studies; Risk Factors; Survival Rate - trends; Thrombolytic Therapy - adverse effects; Thrombolytic Therapy - methods; Treatment Outcome
• ISSN: 1897-5593; 1898-018X; 1898-018X
• DOI: 10.5603/cj.95949

Catheter directed therapies (CDT) are widely used in the treatment of acute pulmonary embolism (PE). A multicenter registry was organized to evaluate their application in real life and to determine efficacy and safety of these procedures. Local experience of participating centers in percutaneous techniques for PE treatment was assessed. An internet-based registry was designed to collect clinical, echocardiographic and laboratory data of consecutive PE patients treated with CDT in participating centers between 2017 and 2022. Under analysis were 145 consecutive patients with acute PE, aged 61 ± 15 years, treated with CDT in 7 centers: 50 (34.5%) patients with high-risk PE (HRPE), and 95 (65.5%) patients with intermediate-high risk PE (IHRPE). 100 (69%) patients were treated with dedicated devices, in 45 (31%) subjects a pigtail catheter was used. Total PE or CDT related in-hospital mortality in HRPE reached 14% (7 patients), while in IHRPE 3.2% (3 patients) (p = 0.032). 50% of PE or CDT related deaths occurred in patients treated with a pigtail catheter. All-cause mortality in 145 patients was 9.7%, and it was higher in HRPE than in IHRPE (18% vs. 5.3%, p = 0.019). The use of pigtail catheters compared to dedicated systems was associated with higher mortality (20% vs. 5%, p = 0.01). Catheter directed therapies is a real option of treating PE. It was used as primary therapy also in patients without contraindication for thrombolysis suggesting that clinical practice does not always follow current PE guidelines. Patients treated with dedicated CDT systems had a higher survival rate than subjects treated with pigtail catheters.