Pseudomonas aeruginosa producing FIM-1-metallo-β-lactamase: emergence and cross-transmission in a long-term acute care rehabilitation hospital

FIM-1 metallo-β-lactamase was previously detected in sporadic clinical isolates. Here, we report on FIM-1-positive from two patients who had shared the same ward in a long-term acute care rehabilitation hospital. Whole-genome sequencing analysis revealed close relatedness of these isolates, which be...

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Published in:Antimicrobial agents and chemotherapy 2024-07, Vol.68 (7), p.e0057424
Main Authors: Antonelli, Alberto, Coppi, Marco, Bonaiuto, Chiara, Giovacchini, Nicla, Grifoni, Camilla, Vaggelli, Guendalina, Pupillo, Roberto, Vannetti, Federica, Farese, Alberto, Viaggi, Bruno, Pollini, Simona, Rossolini, Gian Maria
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antimicrobial Chemotherapy
beta-Lactamases - genetics
beta-Lactamases - metabolism
Cross Infection - microbiology
Hospitals, Rehabilitation
Humans
Male
Mechanisms of Resistance
Microbial Sensitivity Tests
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - genetics
Pseudomonas Infections - drug therapy
Pseudomonas Infections - microbiology
Whole Genome Sequencing
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container_issue 7
container_start_page e0057424
container_title Antimicrobial agents and chemotherapy
container_volume 68
creator Antonelli, Alberto
Coppi, Marco
Bonaiuto, Chiara
Giovacchini, Nicla
Grifoni, Camilla
Vaggelli, Guendalina
Pupillo, Roberto
Vannetti, Federica
Farese, Alberto
Viaggi, Bruno
Pollini, Simona
Rossolini, Gian Maria
description FIM-1 metallo-β-lactamase was previously detected in sporadic clinical isolates. Here, we report on FIM-1-positive from two patients who had shared the same ward in a long-term acute care rehabilitation hospital. Whole-genome sequencing analysis revealed close relatedness of these isolates, which belonged to an ST235 sublineage (clade 8/14) different from those previously reported. Results highlighted the occurrence of clonal diversity among FIM-positive strains and the possibility of their cross-transmission in some healthcare settings.
doi_str_mv 10.1128/aac.00574-24
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source American Society for Microbiology
subjects Anti-Bacterial Agents - pharmacology
Antimicrobial Chemotherapy
beta-Lactamases - genetics
beta-Lactamases - metabolism
Cross Infection - microbiology
Hospitals, Rehabilitation
Humans
Male
Mechanisms of Resistance
Microbial Sensitivity Tests
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - genetics
Pseudomonas Infections - drug therapy
Pseudomonas Infections - microbiology
Whole Genome Sequencing
title Pseudomonas aeruginosa producing FIM-1-metallo-β-lactamase: emergence and cross-transmission in a long-term acute care rehabilitation hospital
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