The emerging role of Piezo1 in the musculoskeletal system and disease

Piezo1, a mechanosensitive ion channel, has emerged as a key player in translating mechanical stimuli into biological signaling. Its involvement extends beyond physiological and pathological processes such as lymphatic vessel development, axon growth, vascular development, immunoregulation, and bloo...

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Bibliographic Details
Published in:Theranostics 2024-01, Vol.14 (10), p.3963-3983
Main Authors: Lei, Lei, Wen, Zhenkang, Cao, Mingde, Zhang, Haozhi, Ling, Samuel Ka-Kin, Fu, Bruma Sai-Chuen, Qin, Ling, Xu, Jiankun, Yung, Patrick Shu-Hang
Format: Article
Language:English
Subjects:
Animals
Chondrogenesis - physiology
Humans
Ion Channels - metabolism
Mechanotransduction, Cellular
Muscle Development
Musculoskeletal Diseases - metabolism
Musculoskeletal System - metabolism
Osteogenesis - physiology
Review
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Summary:Piezo1, a mechanosensitive ion channel, has emerged as a key player in translating mechanical stimuli into biological signaling. Its involvement extends beyond physiological and pathological processes such as lymphatic vessel development, axon growth, vascular development, immunoregulation, and blood pressure regulation. The musculoskeletal system, responsible for structural support, movement, and homeostasis, has recently attracted attention regarding the significance of Piezo1. This review aims to provide a comprehensive summary of the current research on Piezo1 in the musculoskeletal system, highlighting its impact on bone formation, myogenesis, chondrogenesis, intervertebral disc homeostasis, tendon matrix cross-linking, and physical activity. Additionally, we explore the potential of targeting Piezo1 as a therapeutic approach for musculoskeletal disorders, including osteoporosis, muscle atrophy, intervertebral disc degeneration, and osteoarthritis.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.96959