Measurement of iron absorption and iron gains from birth to 6 months in breastfed and formula-fed infants using iron isotope dilution

Little is known about iron kinetics in early infancy. We administered stable iron isotopes to pregnant women and used maternal-fetal iron transfer to enrich newborn body iron. Dilution of enriched body iron by dietary iron with natural isotopic composition was used to assess iron kinetics from birth...

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Bibliographic Details
Published in:Science advances 2024-07, Vol.10 (28), p.eado4262
Main Authors: Stoffel, Nicole U, Cepeda-López, Ana Carla, Zeder, Christophe, Herter-Aeberli, Isabelle, Zimmermann, Michael B
Format: Article
Language:English
Subjects:
Adult
Breast Feeding
Female
Health and Medicine
Humans
Infant
Infant Formula - analysis
Infant Formula - chemistry
Infant, Newborn
Iron - analysis
Iron - metabolism
Iron Isotopes
Male
Pregnancy
Research Methods
SciAdv r-articles
Social and Interdisciplinary Sciences and Public Health
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Summary:Little is known about iron kinetics in early infancy. We administered stable iron isotopes to pregnant women and used maternal-fetal iron transfer to enrich newborn body iron. Dilution of enriched body iron by dietary iron with natural isotopic composition was used to assess iron kinetics from birth to 6 months. In breastfed (BF, n = 8), formula-fed (FF, n = 7), or mixed feeding (MF, n = 8) infants, median (interquartile range) iron intake was 0.27, 11.19 (10.46-15.55), and 4.13 (2.33-6.95) mg/day; iron absorbed was 0.128 (0.095-0.180), 0.457 (0.374-0.617), and 0.391 (0.283-0.473) mg/day (BF versus FF, P < 0.01); and total iron gains were 0.027 (-0.002-0.055), 0.349 (0.260-0.498), and 0.276 (0.175-0.368) mg/day (BF versus FF, P < 0.001; BF versus MF, P < 0.05). Isotope dilution can quantify long-term iron absorption and describe the trajectory of iron depletion during early infancy.
ISSN:2375-2548
2375-2548
DOI:10.1126/sciadv.ado4262