Cushing's syndrome caused by giant Ewing's sarcoma of the kidney: A case report and review of literature

Primary renal Ewing's sarcoma (ES) is extremely rare, and only two cases causing Cushing's syndrome (CS) have been reported to date. We report that the case of an 18-year-old patient is diagnosed primary renal ES with typical CS characterized by purple stripes, weight gain, and hypertensio...

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Bibliographic Details
Published in:World journal of clinical cases 2024-08, Vol.12 (23), p.5431-5440
Main Authors: Dong, Guo-Fan, Hou, Ya-Kun, Ma, Qi, Ma, Shuang-Yu, Wang, Yu-Jie, Rexiati, Mulati, Wang, Wen-Guang
Format: Article
Language:English
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Case Report
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Summary:Primary renal Ewing's sarcoma (ES) is extremely rare, and only two cases causing Cushing's syndrome (CS) have been reported to date. We report that the case of an 18-year-old patient is diagnosed primary renal ES with typical CS characterized by purple stripes, weight gain, and hypertension. CS was first diagnosed by laboratory testing. A huge tumor was revealed in the kidney following an imaging examination. Moreover, brain and bone metastases were observed. After comprehensive treatment, primarily based on surgery, primary renal ES was pathologically diagnosed with a typical genetic mutation through genetic testing. Furthermore, the glucocorticoid level returned to normal. By the ninth postoperative month of follow-up, the patient was recovering well. Cushing-related symptoms had improved, and a satisfactory curative effect was achieved. Primary renal ES, a rare adult malignant tumor, can cause CS and a poor prognosis.
ISSN:2307-8960
2307-8960
DOI:10.12998/wjcc.v12.i23.5431