Design and realization of lung organoid cultures for COVID-19 applications

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has spread globally and threatens public health. Advanced in vitro models that recapitulate the architecture and functioning of specific tissues and organs are in high demand for COVID-19-related patholog...

Full description

Saved in:
Bibliographic Details
Published in:Bio-design and manufacturing 2023-11, Vol.6 (6), p.646-660
Main Authors: Ren, Bing, Chiaravalloti, Tryanni R., Belony, Nadine L., Romero, Diana I., Chai, Wenxuan, Leon, Christopher, Wu, Lizi, Lamango, Nazarius S., Offringa, Ite A., Huang, Yong
Format: Article
Language:English
Subjects:
Animal models
Biomaterials
Biomedical Engineering and Bioengineering
Cell culture
Coronaviruses
COVID-19
Design
Disease transmission
Drug screening
Engineering
Enzymes
Extracellular matrix
Infections
Mechanical Engineering
Medical research
Organoids
Pandemics
Pathogenesis
Physiology
Public health
Respiratory system
Review
Severe acute respiratory syndrome coronavirus 2
Viral infections
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has spread globally and threatens public health. Advanced in vitro models that recapitulate the architecture and functioning of specific tissues and organs are in high demand for COVID-19-related pathology studies and drug screening. Since three-dimensional in vitro cultures, such as self-assembled and engineered organoid cultures, surpass conventional two-dimensional cultures and animal models with respect to increased cellular complexity, an environment more relevant to humans, and reduced cost, they are promising platforms for understanding viral pathogenesis and developing new therapeutics. This review highlights the recent advances in self-assembled and engineered organoid technologies that are used for COVID-19 studies. The challenges and future perspectives are also discussed.
ISSN:2096-5524
2522-8552
2522-8552
DOI:10.1007/s42242-023-00255-1