A Unique Case of Intracranial Bifocal Germinoma

Primary intracranial germ cell tumors are rare tumors that often occur in children and young adults. We report a case of a 17-year-old male, who presented with vomiting, headache, and blurring of vision of the left eye on the temporal aspect for two months. His biological assessment showed panhypopi...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-06, Vol.16 (6), p.e62167
Main Authors: Chetana Naga Sai, Tarani, Narayanan, Ramakrishna, Uppin, Megha S, Kanala, Ramanadha Reddy
Format: Article
Language:English
Subjects:
Biomarkers
Biopsy
Brain cancer
Chemotherapy
Dehydrogenases
Endocrine system
Endoscopy
Growth hormones
Histopathology
Hydrocephalus
Hypothalamus
Insulin-like growth factors
Magnetic resonance imaging
Metastasis
Radiation therapy
Radiology
Thyroid gland
Tumors
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Summary:Primary intracranial germ cell tumors are rare tumors that often occur in children and young adults. We report a case of a 17-year-old male, who presented with vomiting, headache, and blurring of vision of the left eye on the temporal aspect for two months. His biological assessment showed panhypopituitarism. Serum markers showed elevated beta human chorionic gonadotropin and lactate dehydrogenase. A solid cystic lesion was noted on imaging, involving the sella, parasellar region, and pineal region with calcifications within. Diagnosis of bifocal germinoma was confirmed by tumor biopsy. The treatment protocol for the patient involved four cycles of chemotherapy using etoposide and carboplatin, followed by a course of radiotherapy.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.62167