Comparative Analysis of Retinal Structural and Angiographic Parameters in Diabetic Patients, Alzheimer's Disease Patients, and Healthy Controls: An OCT-Based Study

• Published in: Romanian journal of ophthalmology 2024-04, Vol.68 (2), p.143-147
• Main Authors: Borodi, Paul-Gabriel, Slevin, Mark, Hopulele-Petri, Andrei, Crainic, Anca, Pop, Pușa, Gavriș, Iulia-Maria, Gavriș, Maria-Monica
• Format: Article
• Language: English
• Subjects: Aged; Alzheimer Disease - diagnosis; Cross-Sectional Studies; Diabetic Retinopathy - diagnosis; Female; Fluorescein Angiography - methods; Fundus Oculi; Humans; Male; Middle Aged; Nerve Fibers - pathology; Retinal Ganglion Cells - pathology; Tomography, Optical Coherence - methods
• ISSN: 2457-4325; 2501-2533; 2501-2533
• DOI: 10.22336/rjo.2024.26

This study aimed to investigate the potential connections between Alzheimer's Disease (AD) and diabetes. This is a cross-sectional study in which AD and diabetes patients sent by the Psychiatry and Diabetes Departments for ophthalmological screening were observed for inclusion/exclusion criteria. Patients were divided into two comparison groups. The first group (n=3) consisted of the age-matched normal and diabetic patient of the stage 3 AD disease participant. The second group (n=3) was for the stage 5 AD patient with diabetes and normal age-matched controls. Each patient underwent a full ophthalmological examination and SS-OCT (Swept Source-Ocular Computer Tomography) for retinal evaluation. A total of 6 patients (12 eyes) were obtained, three men and three women. In the early AD group, the patient with diabetes showed lower macular thickness compared to other groups. In the nasal-inferior (NI) and temporal-superior (TS) ganglion cell layer (GCL), the AD patient showed statistically significant lower values compared to the other patients. In the moderately severe AD group, we found that the AD patient had lower retinal nerve fiber layer (RNFL) thickness on the temporal side compared to the rest of the patients and both the AD patient and diabetes patient showed lower RNFL thickness in the nasal-superior (NS) quadrant. Also, the foveal avascular zone (FAZ) area was statistically significantly lower for both the diabetes and AD patients compared to the healthy control. In conclusion, distinct retinal findings associated with AD and diabetes in young and elderly patients were revealed in our study. The clinical implications and potential interplay between these conditions need to be elucidated by further research. AD = Alzheimer's Disease, SS-OCT = Swept Source - Ocular Computer Tomography, GCL = Ganglion cell layer, RNFL = Retinal nerve fiber layer, FAZ = foveal avascular zone.