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A comprehensive evaluation of imaging features in pediatric spinal gliomas and their value in predicting tumor grade and histology
Purpose Pediatric spinal cord gliomas (PSGs) are rare in children and few reports detail their imaging features. We tested the association of tumoral grade with imaging features and proposed a novel approach to categorize post-contrast enhancement patterns in PSGs. Methods This single-center, retros...
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| Published in: | Neuroradiology 2024-08, Vol.66 (8), p.1311-1324 |
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| container_title | Neuroradiology |
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| creator | Cerron-Vela, Carmen Rosa Gonçalves, Fabrício Guimarães Tierradentro-García, Luis Octavio Viaene, Angela N Lerebo, Wondwossen Andronikou, Savvas |
| description | Purpose
Pediatric spinal cord gliomas (PSGs) are rare in children and few reports detail their imaging features. We tested the association of tumoral grade with imaging features and proposed a novel approach to categorize post-contrast enhancement patterns in PSGs.
Methods
This single-center, retrospective study included patients |
| doi_str_mv | 10.1007/s00234-024-03395-y |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11246280</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3070837644</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-7aeede1857057f4e589f5ffd16acabb5a6bdc3c2dd2aa9431f5c6b1122bf62dc3</originalsourceid><addsrcrecordid>eNp9kTtvFDEURi1ERJbAH6BAlmhohvgxzwpFES8pUhqorTue61lHM_Zge1baNr8c724IjyKF5eI79_jxEfKGsw-cseYyMiZkWTCRl5RdVeyfkQ0vpSh4J9hzssl5W8iuZOfkZYx3jDHZyOYFOZdtl6dauSH3V1T7eQm4RRftDinuYFohWe-oN9TOMFo3UoOQ1oCRWkcXHCykYDWNi3Uw0XGyfoZIwQ00bdEGenDgkQ0Z1umgSOvsAx0DDHgktzYmP_lx_4qcGZgivn7YL8iPz5--X38tbm6_fLu-uil0KepUNIA4IG-rhlWNKbFqO1MZM_AaNPR9BXU_aKnFMAiArpTcVLruOReiN7XI0QX5ePIuaz_joNGlAJNaQn5k2CsPVv2bOLtVo9-p7Chr0bJseP9gCP7nijGp2UaN0wQO_RqVZA1rZVOXZUbf_Yfe-TXk3zpSXXeoosqUOFE6-BgDmsfbcKYOHatTxyq3pY4dq30eevv3Ox5HfpeaAXkCYo7ciOHP2U9ofwEco7cA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3079900375</pqid></control><display><type>article</type><title>A comprehensive evaluation of imaging features in pediatric spinal gliomas and their value in predicting tumor grade and histology</title><source>Springer Nature</source><creator>Cerron-Vela, Carmen Rosa ; Gonçalves, Fabrício Guimarães ; Tierradentro-García, Luis Octavio ; Viaene, Angela N ; Lerebo, Wondwossen ; Andronikou, Savvas</creator><creatorcontrib>Cerron-Vela, Carmen Rosa ; Gonçalves, Fabrício Guimarães ; Tierradentro-García, Luis Octavio ; Viaene, Angela N ; Lerebo, Wondwossen ; Andronikou, Savvas</creatorcontrib><description>Purpose
Pediatric spinal cord gliomas (PSGs) are rare in children and few reports detail their imaging features. We tested the association of tumoral grade with imaging features and proposed a novel approach to categorize post-contrast enhancement patterns in PSGs.
Methods
This single-center, retrospective study included patients <21 years of age with preoperative spinal MRI and confirmed pathological diagnosis of PSG from 2000-2022. Tumors were classified using the 5th edition of the WHO CNS Tumors Classification. Two radiologists reviewed multiple imaging features, and classified enhancement patterns using a novel approach. Fisher's exact test determined associations between imaging and histological features.
Results
Forty-one PSGs were reviewed. Thirty-four were intramedullary, and seven were extramedullary. Pilocytic astrocytoma was the most common tumor (39.02%). Pain and weakness were the most prevalent symptoms. Seven patients (17.07%) died. Cyst, syringomyelia, and leptomeningeal enhancement were associated with tumor grade. Widening of the spinal canal was observed only in low-grade astrocytomas. There was a significant association between tumor grade and contrast enhancement pattern. Specifically, low-grade PSGs were more likely to exhibit type 1A enhancement (mass-like, with well-defined enhancing margins) and less likely to exhibit type 1B enhancement (mass-like, with ill-defined enhancing margins).
Conclusion
PSGs display overlapping imaging features, making grade differentiation challenging based solely on imaging. The correlation between tumor grade and contrast enhancement patterns suggests a potential diagnostic avenue, requiring further validation with larger, multicenter studies. Furthermore, Low-grade PSGs display cysts and syringomyelia more frequently, and leptomeningeal enhancement is less common.</description><identifier>ISSN: 0028-3940</identifier><identifier>ISSN: 1432-1920</identifier><identifier>EISSN: 1432-1920</identifier><identifier>DOI: 10.1007/s00234-024-03395-y</identifier><identifier>PMID: 38902483</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Astrocytoma ; Brain tumors ; Child ; Child, Preschool ; Contrast Media ; Diagnostic Neuroradiology ; Female ; Glioma ; Glioma - diagnostic imaging ; Glioma - pathology ; Histology ; Humans ; Imaging ; Infant ; Magnetic Resonance Imaging - methods ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Meninges ; Neoplasm Grading ; Neurology ; Neuroradiology ; Neurosciences ; Neurosurgery ; Pediatrics ; Radiology ; Retrospective Studies ; Spinal cord ; Spinal Cord Neoplasms - diagnostic imaging ; Spinal Cord Neoplasms - pathology ; Tumors</subject><ispartof>Neuroradiology, 2024-08, Vol.66 (8), p.1311-1324</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c426t-7aeede1857057f4e589f5ffd16acabb5a6bdc3c2dd2aa9431f5c6b1122bf62dc3</cites><orcidid>0000-0002-7881-6021</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38902483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cerron-Vela, Carmen Rosa</creatorcontrib><creatorcontrib>Gonçalves, Fabrício Guimarães</creatorcontrib><creatorcontrib>Tierradentro-García, Luis Octavio</creatorcontrib><creatorcontrib>Viaene, Angela N</creatorcontrib><creatorcontrib>Lerebo, Wondwossen</creatorcontrib><creatorcontrib>Andronikou, Savvas</creatorcontrib><title>A comprehensive evaluation of imaging features in pediatric spinal gliomas and their value in predicting tumor grade and histology</title><title>Neuroradiology</title><addtitle>Neuroradiology</addtitle><addtitle>Neuroradiology</addtitle><description>Purpose
Pediatric spinal cord gliomas (PSGs) are rare in children and few reports detail their imaging features. We tested the association of tumoral grade with imaging features and proposed a novel approach to categorize post-contrast enhancement patterns in PSGs.
Methods
This single-center, retrospective study included patients <21 years of age with preoperative spinal MRI and confirmed pathological diagnosis of PSG from 2000-2022. Tumors were classified using the 5th edition of the WHO CNS Tumors Classification. Two radiologists reviewed multiple imaging features, and classified enhancement patterns using a novel approach. Fisher's exact test determined associations between imaging and histological features.
Results
Forty-one PSGs were reviewed. Thirty-four were intramedullary, and seven were extramedullary. Pilocytic astrocytoma was the most common tumor (39.02%). Pain and weakness were the most prevalent symptoms. Seven patients (17.07%) died. Cyst, syringomyelia, and leptomeningeal enhancement were associated with tumor grade. Widening of the spinal canal was observed only in low-grade astrocytomas. There was a significant association between tumor grade and contrast enhancement pattern. Specifically, low-grade PSGs were more likely to exhibit type 1A enhancement (mass-like, with well-defined enhancing margins) and less likely to exhibit type 1B enhancement (mass-like, with ill-defined enhancing margins).
Conclusion
PSGs display overlapping imaging features, making grade differentiation challenging based solely on imaging. The correlation between tumor grade and contrast enhancement patterns suggests a potential diagnostic avenue, requiring further validation with larger, multicenter studies. Furthermore, Low-grade PSGs display cysts and syringomyelia more frequently, and leptomeningeal enhancement is less common.</description><subject>Adolescent</subject><subject>Astrocytoma</subject><subject>Brain tumors</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Contrast Media</subject><subject>Diagnostic Neuroradiology</subject><subject>Female</subject><subject>Glioma</subject><subject>Glioma - diagnostic imaging</subject><subject>Glioma - pathology</subject><subject>Histology</subject><subject>Humans</subject><subject>Imaging</subject><subject>Infant</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meninges</subject><subject>Neoplasm Grading</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Pediatrics</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Spinal cord</subject><subject>Spinal Cord Neoplasms - diagnostic imaging</subject><subject>Spinal Cord Neoplasms - pathology</subject><subject>Tumors</subject><issn>0028-3940</issn><issn>1432-1920</issn><issn>1432-1920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kTtvFDEURi1ERJbAH6BAlmhohvgxzwpFES8pUhqorTue61lHM_Zge1baNr8c724IjyKF5eI79_jxEfKGsw-cseYyMiZkWTCRl5RdVeyfkQ0vpSh4J9hzssl5W8iuZOfkZYx3jDHZyOYFOZdtl6dauSH3V1T7eQm4RRftDinuYFohWe-oN9TOMFo3UoOQ1oCRWkcXHCykYDWNi3Uw0XGyfoZIwQ00bdEGenDgkQ0Z1umgSOvsAx0DDHgktzYmP_lx_4qcGZgivn7YL8iPz5--X38tbm6_fLu-uil0KepUNIA4IG-rhlWNKbFqO1MZM_AaNPR9BXU_aKnFMAiArpTcVLruOReiN7XI0QX5ePIuaz_joNGlAJNaQn5k2CsPVv2bOLtVo9-p7Chr0bJseP9gCP7nijGp2UaN0wQO_RqVZA1rZVOXZUbf_Yfe-TXk3zpSXXeoosqUOFE6-BgDmsfbcKYOHatTxyq3pY4dq30eevv3Ox5HfpeaAXkCYo7ciOHP2U9ofwEco7cA</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Cerron-Vela, Carmen Rosa</creator><creator>Gonçalves, Fabrício Guimarães</creator><creator>Tierradentro-García, Luis Octavio</creator><creator>Viaene, Angela N</creator><creator>Lerebo, Wondwossen</creator><creator>Andronikou, Savvas</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7881-6021</orcidid></search><sort><creationdate>20240801</creationdate><title>A comprehensive evaluation of imaging features in pediatric spinal gliomas and their value in predicting tumor grade and histology</title><author>Cerron-Vela, Carmen Rosa ; Gonçalves, Fabrício Guimarães ; Tierradentro-García, Luis Octavio ; Viaene, Angela N ; Lerebo, Wondwossen ; Andronikou, Savvas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-7aeede1857057f4e589f5ffd16acabb5a6bdc3c2dd2aa9431f5c6b1122bf62dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Astrocytoma</topic><topic>Brain tumors</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Contrast Media</topic><topic>Diagnostic Neuroradiology</topic><topic>Female</topic><topic>Glioma</topic><topic>Glioma - diagnostic imaging</topic><topic>Glioma - pathology</topic><topic>Histology</topic><topic>Humans</topic><topic>Imaging</topic><topic>Infant</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meninges</topic><topic>Neoplasm Grading</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Pediatrics</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Spinal cord</topic><topic>Spinal Cord Neoplasms - diagnostic imaging</topic><topic>Spinal Cord Neoplasms - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cerron-Vela, Carmen Rosa</creatorcontrib><creatorcontrib>Gonçalves, Fabrício Guimarães</creatorcontrib><creatorcontrib>Tierradentro-García, Luis Octavio</creatorcontrib><creatorcontrib>Viaene, Angela N</creatorcontrib><creatorcontrib>Lerebo, Wondwossen</creatorcontrib><creatorcontrib>Andronikou, Savvas</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroradiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cerron-Vela, Carmen Rosa</au><au>Gonçalves, Fabrício Guimarães</au><au>Tierradentro-García, Luis Octavio</au><au>Viaene, Angela N</au><au>Lerebo, Wondwossen</au><au>Andronikou, Savvas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comprehensive evaluation of imaging features in pediatric spinal gliomas and their value in predicting tumor grade and histology</atitle><jtitle>Neuroradiology</jtitle><stitle>Neuroradiology</stitle><addtitle>Neuroradiology</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>66</volume><issue>8</issue><spage>1311</spage><epage>1324</epage><pages>1311-1324</pages><issn>0028-3940</issn><issn>1432-1920</issn><eissn>1432-1920</eissn><abstract>Purpose
Pediatric spinal cord gliomas (PSGs) are rare in children and few reports detail their imaging features. We tested the association of tumoral grade with imaging features and proposed a novel approach to categorize post-contrast enhancement patterns in PSGs.
Methods
This single-center, retrospective study included patients <21 years of age with preoperative spinal MRI and confirmed pathological diagnosis of PSG from 2000-2022. Tumors were classified using the 5th edition of the WHO CNS Tumors Classification. Two radiologists reviewed multiple imaging features, and classified enhancement patterns using a novel approach. Fisher's exact test determined associations between imaging and histological features.
Results
Forty-one PSGs were reviewed. Thirty-four were intramedullary, and seven were extramedullary. Pilocytic astrocytoma was the most common tumor (39.02%). Pain and weakness were the most prevalent symptoms. Seven patients (17.07%) died. Cyst, syringomyelia, and leptomeningeal enhancement were associated with tumor grade. Widening of the spinal canal was observed only in low-grade astrocytomas. There was a significant association between tumor grade and contrast enhancement pattern. Specifically, low-grade PSGs were more likely to exhibit type 1A enhancement (mass-like, with well-defined enhancing margins) and less likely to exhibit type 1B enhancement (mass-like, with ill-defined enhancing margins).
Conclusion
PSGs display overlapping imaging features, making grade differentiation challenging based solely on imaging. The correlation between tumor grade and contrast enhancement patterns suggests a potential diagnostic avenue, requiring further validation with larger, multicenter studies. Furthermore, Low-grade PSGs display cysts and syringomyelia more frequently, and leptomeningeal enhancement is less common.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38902483</pmid><doi>10.1007/s00234-024-03395-y</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-7881-6021</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Astrocytoma Brain tumors Child Child, Preschool Contrast Media Diagnostic Neuroradiology Female Glioma Glioma - diagnostic imaging Glioma - pathology Histology Humans Imaging Infant Magnetic Resonance Imaging - methods Male Medical imaging Medicine Medicine & Public Health Meninges Neoplasm Grading Neurology Neuroradiology Neurosciences Neurosurgery Pediatrics Radiology Retrospective Studies Spinal cord Spinal Cord Neoplasms - diagnostic imaging Spinal Cord Neoplasms - pathology Tumors |
| title | A comprehensive evaluation of imaging features in pediatric spinal gliomas and their value in predicting tumor grade and histology |
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