Effect of apolipoprotein E ε4 and its modification by sociodemographic characteristics on cognitive measures in South Asians from LASI‐DAD

BACKGROUND We investigated the effects of apolipoprotein E (APOE) ε4 and its interactions with sociodemographic characteristics on cognitive measures in South Asians from the Diagnostic Assessment of Dementia for the Longitudinal Aging Study of India (LASI‐DAD). METHODS Linear regression was used to...

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Bibliographic Details
Published in:Alzheimer's & dementia 2024-07, Vol.20 (7), p.4854-4867
Main Authors: Wang, Yi Zhe, Zhao, Wei, Moorjani, Priya, Gross, Alden L., Zhou, Xiang, Dey, Aparajit B., Lee, Jinkook, Smith, Jennifer A., Kardia, Sharon L. R.
Format: Article
Language:English
Subjects:
Aged
APOE
Apolipoprotein E4 - genetics
Asian People
Cognition - physiology
cognitive function
dementia
Female
Humans
India
India - ethnology
interaction
Longitudinal Studies
Male
Middle Aged
Neuropsychological Tests - statistics & numerical data
sociodemographic characteristics
Sociodemographic Factors
South Asian
South Asian People
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Summary:BACKGROUND We investigated the effects of apolipoprotein E (APOE) ε4 and its interactions with sociodemographic characteristics on cognitive measures in South Asians from the Diagnostic Assessment of Dementia for the Longitudinal Aging Study of India (LASI‐DAD). METHODS Linear regression was used to assess the association between APOE ε4 and global‐ and domain‐specific cognitive function in 2563 participants (mean age 69.6 ± 7.3 years; 53% female). Effect modification by age, sex, and education were explored using interaction terms and subgroup analyses. RESULTS APOE ε4 was inversely associated with most cognitive measures (p 
ISSN:1552-5260
1552-5279
1552-5279
DOI:10.1002/alz.14052