Assessing anorectal function in patients with recurrent ulcerative colitis

Purpose Ulcerative colitis (UC) is an inflammatory bowel disease with an unclear etiology that can lead to irreversible changes in distal colonic function in chronic patients. This study investigated anorectal function in recurrent UC patients and identified influencing factors. Methods This prospec...

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Bibliographic Details
Published in:International journal of colorectal disease 2024-07, Vol.39 (1), p.110, Article 110
Main Authors: Wu, Qiaoyan, Li, Tongyu, Deng, Fenglian, Yao, Xuejie, Chen, Xueqin, Jiang, Qi, Ding, Xiaoyun
Format: Article
Language:English
Subjects:
Adult
Anal Canal - physiopathology
Anorectal
Anxiety
Anxiety - physiopathology
Colitis, Ulcerative - physiopathology
Colitis, Ulcerative - psychology
Defecation
Defecation - physiology
Fecal incontinence
Fecal Incontinence - etiology
Fecal Incontinence - physiopathology
Fecal Incontinence - psychology
Feces
Feces - chemistry
Female
Gastroenterology
Hepatology
Humans
Inflammatory bowel disease
Inflammatory bowel diseases
Internal Medicine
Intestine
Leukocyte L1 Antigen Complex - analysis
Leukocyte L1 Antigen Complex - metabolism
Male
Medicine
Medicine & Public Health
Middle Aged
Proctology
Prospective Studies
Quality of life
Rectum - physiopathology
Recurrence
Surgery
Ulcerative colitis
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Summary:Purpose Ulcerative colitis (UC) is an inflammatory bowel disease with an unclear etiology that can lead to irreversible changes in distal colonic function in chronic patients. This study investigated anorectal function in recurrent UC patients and identified influencing factors. Methods This prospective study enrolled 33 recurrent UC patients and 40 newly diagnosed patients from January 2019 to December 2022. Data collection included clinical records, scores, and anorectal function assessments. Regression analyses were used to identify factors impacting anorectal function. Results Recurrent UC patients had higher baseline CRP and fecal calprotectin levels, increased anxiety and depression, and more severe fecal incontinence. They also had lower BMIs, serum Hb and albumin (ALB) levels, and Inflammatory Bowel Disease Questionnaire scores than did initial-onset UC patients. Multivariate linear regression analysis revealed that long disease duration (coef. − 0.376, P  
ISSN:1432-1262
0179-1958
1432-1262
DOI:10.1007/s00384-024-04680-1