The Role of Glia Telomere Dysfunction in the Pathogenesis of Central Nervous System Diseases

Maintaining the telomere length is decisive for the viability and homeostasis process of all the cells of an organism, including human glial cells. Telomere shortening of microglial cells has been widely associated with the onset and progression of neurodegenerative diseases such as Parkinson’s and...

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Bibliographic Details
Published in:Molecular neurobiology 2024-08, Vol.61 (8), p.5868-5881
Main Authors: Papageorgakopoulou, Manthia A., Bania, Angelina, Lagogianni, Ioanna-Aglaia, Birmpas, Kyriakos, Assimakopoulou, Martha
Format: Article
Language:English
Subjects:
Alzheimer's disease
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Central nervous system
Central nervous system diseases
Central Nervous System Diseases - metabolism
Central Nervous System Diseases - pathology
Glial cells
Glioma cells
Homeostasis
Homologous recombination
Humans
Mental disorders
Microglia
Microglial cells
Nervous system
Neurobiology
Neurodegenerative diseases
Neuroglia - metabolism
Neuroglia - pathology
Neurology
Neuronal-glial interactions
Neurosciences
Pathogenesis
Telomere - metabolism
Telomeres
Therapeutic targets
Traumatic brain injury
Yeast
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Summary:Maintaining the telomere length is decisive for the viability and homeostasis process of all the cells of an organism, including human glial cells. Telomere shortening of microglial cells has been widely associated with the onset and progression of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. Additionally, traumatic brain injury appears to have a positive correlation with the telomere-shortening process of microglia, and telomere length can be used as a non-invasive biomarker for the clinical management of these patients. Moreover, telomere involvement through telomerase reactivation and homologous recombination also known as the alternative lengthening of telomeres (ALT) has been described in gliomagenesis pathways, and particular focus has been given in the translational significance of these mechanisms in gliomas diagnosis and prognostic classification. Finally, glia telomere shortening is implicated in some psychiatric diseases. Given that telomere dysfunction of glial cells is involved in the central nervous system (CNS) disease pathogenesis, it represents a promising drug target that could lead to the incorporation of new tools in the medicinal arsenal for the management of so far incurable conditions.
ISSN:0893-7648
1559-1182
1559-1182
DOI:10.1007/s12035-024-03947-6