Sjogren's Antibodies and Neonatal Lupus: A Scoping Review

Sjogren's syndrome (SS) is an autoimmune disease characterized by inflammation of exocrine glands. The disorder predominantly affects middle-aged women. Autoantibodies, including anti-SS-A/Ro and anti-SS-B/La antibodies, are present in most cases of SS. These antibodies can cross the placenta a...

Full description

Saved in:
Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-06, Vol.16 (6), p.e62528
Main Authors: Nagliya, Deepika, Castellano, Courteney, Demory, Michelle L, Kesselman, Marc M
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Autoimmune diseases
Birth weight
Blood diseases
Cardiology
Congenital diseases
Connective tissue
Diabetes
Exocrine glands
Heart
Hypertension
Lupus
Medical research
Newborn babies
Obstetrics/Gynecology
Pregnancy
Pregnancy complications
Psoriasis
Rheumatoid arthritis
Rheumatology
Thrombocytopenia
Womens health
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sjogren's syndrome (SS) is an autoimmune disease characterized by inflammation of exocrine glands. The disorder predominantly affects middle-aged women. Autoantibodies, including anti-SS-A/Ro and anti-SS-B/La antibodies, are present in most cases of SS. These antibodies can cross the placenta and likely play a role in pregnancy complications as well as the development of neonatal lupus, resulting in congenital heart block (CHB). It is essential to monitor the fetus for CHB during pregnancy. In particular, screening with echocardiography and monitoring heart rate at home are recommended practices. Regarding medical management, hydroxychloroquine and glucocorticoids have shown promise in reducing cardiac manifestations, but further research is needed to elucidate their longer term efficacy and safety. This scoping review analyzes literature from 2001 to 2024, focusing on pregnancy outcomes among women with SS, clinical manifestations of neonatal lupus, the role of anti-SS-A/Ro and anti-SS-B/La antibodies in the development of neonatal lupus and CHB, and emphasizes the need for future research efforts to refine treatment protocols and enhance clinical care strategies for pregnant women with SS.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.62528