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Mapping the Grounds for Mortalities in Acute Myeloid Leukemia Through Registry Analyses: A Retrospective Cohort Study of Children, Adolescents, and Young Adults Patients
Our objective was to identify non-malignant factors that contribute to mortality in children, adolescents and young adults, aiming to improve patient follow-up and reduce mortality rates to achieve better survival outcomes. We analyzed 8,239 acute myeloid leukemia (AML) cases diagnosed between 2000...
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Published in: | Journal of clinical medicine research 2024-06, Vol.16 (6), p.310-318 |
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creator | Elgenidy, Anas Al-Kurdi, Mohammed Al-Mahdi Ibrahim, Hoda Atef Abdelsattar Gad, Eman F Awad, Ahmed K Caruana, Rebecca Diacono, Sheriseane Sherif, Aya Elattar, Tasneem Al-Ghanam, Islam E Eldmaty, Asmaa M Abubasheer, Tareq M Afifi, Ahmed M Elhoufey, Amira Dailah, Hamad Ghaleb Osman, Amira M Ezzat, Mohamed Gamal, Doaa Ali Elmonier, Rady Hammour, Ahmed El-Sayed Abougabal, Maged T Saad, Khaled |
description | Our objective was to identify non-malignant factors that contribute to mortality in children, adolescents and young adults, aiming to improve patient follow-up and reduce mortality rates to achieve better survival outcomes.
We analyzed 8,239 acute myeloid leukemia (AML) cases diagnosed between 2000 and 2019 in the USA. Using version 8.4.0.1 of the Surveillance, Epidemiology, and End Results (SEER)*Stat software, we calculated the standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) for each cause of death.
Out of the 3,165 deaths observed in the study population, the majority (2,245;70.9%) were attributed to AML itself, followed by non-AML cancers (573; 18.1%) and non-cancerous causes (347; 10.9%).
Patients with AML are at a higher risk of developing other types of cancer and granulocyte deficiencies, which increases the risk of death from non-cancerous causes such as infections. Moreover, treatment for AML carries the risk of cardiac problems. AML is commoner in males than females. |
doi_str_mv | 10.14740/jocmr5205 |
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We analyzed 8,239 acute myeloid leukemia (AML) cases diagnosed between 2000 and 2019 in the USA. Using version 8.4.0.1 of the Surveillance, Epidemiology, and End Results (SEER)*Stat software, we calculated the standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) for each cause of death.
Out of the 3,165 deaths observed in the study population, the majority (2,245;70.9%) were attributed to AML itself, followed by non-AML cancers (573; 18.1%) and non-cancerous causes (347; 10.9%).
Patients with AML are at a higher risk of developing other types of cancer and granulocyte deficiencies, which increases the risk of death from non-cancerous causes such as infections. Moreover, treatment for AML carries the risk of cardiac problems. AML is commoner in males than females.</description><identifier>ISSN: 1918-3003</identifier><identifier>EISSN: 1918-3011</identifier><identifier>DOI: 10.14740/jocmr5205</identifier><identifier>PMID: 39027809</identifier><language>eng</language><publisher>Canada: Elmer Press</publisher><subject>Original</subject><ispartof>Journal of clinical medicine research, 2024-06, Vol.16 (6), p.310-318</ispartof><rights>Copyright 2024, Elgenidy et al.</rights><rights>Copyright 2024, Elgenidy et al. 2024</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-8473-6116 ; 0000-0001-5399-8861</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11254311/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11254311/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39027809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elgenidy, Anas</creatorcontrib><creatorcontrib>Al-Kurdi, Mohammed Al-Mahdi</creatorcontrib><creatorcontrib>Ibrahim, Hoda Atef Abdelsattar</creatorcontrib><creatorcontrib>Gad, Eman F</creatorcontrib><creatorcontrib>Awad, Ahmed K</creatorcontrib><creatorcontrib>Caruana, Rebecca</creatorcontrib><creatorcontrib>Diacono, Sheriseane</creatorcontrib><creatorcontrib>Sherif, Aya</creatorcontrib><creatorcontrib>Elattar, Tasneem</creatorcontrib><creatorcontrib>Al-Ghanam, Islam E</creatorcontrib><creatorcontrib>Eldmaty, Asmaa M</creatorcontrib><creatorcontrib>Abubasheer, Tareq M</creatorcontrib><creatorcontrib>Afifi, Ahmed M</creatorcontrib><creatorcontrib>Elhoufey, Amira</creatorcontrib><creatorcontrib>Dailah, Hamad Ghaleb</creatorcontrib><creatorcontrib>Osman, Amira M</creatorcontrib><creatorcontrib>Ezzat, Mohamed</creatorcontrib><creatorcontrib>Gamal, Doaa Ali</creatorcontrib><creatorcontrib>Elmonier, Rady</creatorcontrib><creatorcontrib>Hammour, Ahmed El-Sayed</creatorcontrib><creatorcontrib>Abougabal, Maged T</creatorcontrib><creatorcontrib>Saad, Khaled</creatorcontrib><title>Mapping the Grounds for Mortalities in Acute Myeloid Leukemia Through Registry Analyses: A Retrospective Cohort Study of Children, Adolescents, and Young Adults Patients</title><title>Journal of clinical medicine research</title><addtitle>J Clin Med Res</addtitle><description>Our objective was to identify non-malignant factors that contribute to mortality in children, adolescents and young adults, aiming to improve patient follow-up and reduce mortality rates to achieve better survival outcomes.
We analyzed 8,239 acute myeloid leukemia (AML) cases diagnosed between 2000 and 2019 in the USA. Using version 8.4.0.1 of the Surveillance, Epidemiology, and End Results (SEER)*Stat software, we calculated the standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) for each cause of death.
Out of the 3,165 deaths observed in the study population, the majority (2,245;70.9%) were attributed to AML itself, followed by non-AML cancers (573; 18.1%) and non-cancerous causes (347; 10.9%).
Patients with AML are at a higher risk of developing other types of cancer and granulocyte deficiencies, which increases the risk of death from non-cancerous causes such as infections. Moreover, treatment for AML carries the risk of cardiac problems. AML is commoner in males than females.</description><subject>Original</subject><issn>1918-3003</issn><issn>1918-3011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpVkc1u1DAUhSMEolXphgdAd4lQp_gnzg8bFI2gRZoRCMqCleWJbxIXJw62UymPxFtiaBmBN7buPf58fE-WPafkkuZlTl7funb0ghHxKDulNa02nFD6-Hgm_CQ7D-GWpMU5rUj1NDvhNWFlRerT7OdezbOZeogDwpV3y6QDdM7D3vmorIkGA5gJmnaJCPsVrTMadrh8x9EouBnSlX6Az9ibEP0KzaTsGjC8gSYVo3dhxjaaO4StGxISvsRFr-A62A7Gao_TBTTaWQwtTjFcgJo0fEs2-lRebAzwSSUPqfUse9IpG_D8YT_Lvr5_d7O93uw-Xn3YNrtNy4oqbnTJyqJltOqEoMgZI0xxVAfe5lqJmmnKhGCUVchKUosiL8oyz9MssNC0PAh-lr29587LYUT925ZXVs7ejMqv0ikj_-9MZpC9u5M0kXNOaSK8fCB492PBEOVo0vesVRO6JUhOKlawqmB1kr66l7ZpUsFjd3yHEvknX3nMN4lf_OvsKP2bJv8FZ16jhQ</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Elgenidy, Anas</creator><creator>Al-Kurdi, Mohammed Al-Mahdi</creator><creator>Ibrahim, Hoda Atef Abdelsattar</creator><creator>Gad, Eman F</creator><creator>Awad, Ahmed K</creator><creator>Caruana, Rebecca</creator><creator>Diacono, Sheriseane</creator><creator>Sherif, Aya</creator><creator>Elattar, Tasneem</creator><creator>Al-Ghanam, Islam E</creator><creator>Eldmaty, Asmaa M</creator><creator>Abubasheer, Tareq M</creator><creator>Afifi, Ahmed M</creator><creator>Elhoufey, Amira</creator><creator>Dailah, Hamad Ghaleb</creator><creator>Osman, Amira M</creator><creator>Ezzat, Mohamed</creator><creator>Gamal, Doaa Ali</creator><creator>Elmonier, Rady</creator><creator>Hammour, Ahmed El-Sayed</creator><creator>Abougabal, Maged T</creator><creator>Saad, Khaled</creator><general>Elmer Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8473-6116</orcidid><orcidid>https://orcid.org/0000-0001-5399-8861</orcidid></search><sort><creationdate>202406</creationdate><title>Mapping the Grounds for Mortalities in Acute Myeloid Leukemia Through Registry Analyses: A Retrospective Cohort Study of Children, Adolescents, and Young Adults Patients</title><author>Elgenidy, Anas ; 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We analyzed 8,239 acute myeloid leukemia (AML) cases diagnosed between 2000 and 2019 in the USA. Using version 8.4.0.1 of the Surveillance, Epidemiology, and End Results (SEER)*Stat software, we calculated the standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) for each cause of death.
Out of the 3,165 deaths observed in the study population, the majority (2,245;70.9%) were attributed to AML itself, followed by non-AML cancers (573; 18.1%) and non-cancerous causes (347; 10.9%).
Patients with AML are at a higher risk of developing other types of cancer and granulocyte deficiencies, which increases the risk of death from non-cancerous causes such as infections. Moreover, treatment for AML carries the risk of cardiac problems. AML is commoner in males than females.</abstract><cop>Canada</cop><pub>Elmer Press</pub><pmid>39027809</pmid><doi>10.14740/jocmr5205</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8473-6116</orcidid><orcidid>https://orcid.org/0000-0001-5399-8861</orcidid><oa>free_for_read</oa></addata></record> |
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title | Mapping the Grounds for Mortalities in Acute Myeloid Leukemia Through Registry Analyses: A Retrospective Cohort Study of Children, Adolescents, and Young Adults Patients |
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