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Pediatric Uropathogens and their Antimicrobial Susceptibility Pattern: Experience from an Impoverished District of Karachi, Pakistan
Urinary tract infection (UTI) is the most common infection of the pediatric age group. Several factors linked to higher prevalence include poor personal hygiene, improper sanitation, lower socioeconomic status, and malnourishment. In addition to having a worse quality of life, the 1.8 million childr...
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Published in: | Clinical medicine insights. Pediatrics 2024-01, Vol.18, p.11795565241254321 |
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description | Urinary tract infection (UTI) is the most common infection of the pediatric age group. Several factors linked to higher prevalence include poor personal hygiene, improper sanitation, lower socioeconomic status, and malnourishment. In addition to having a worse quality of life, the 1.8 million children who live in Karachi's Korangi district are routinely exposed to such factors.
The study aims to evaluate the frequency of UTI and distribution of uropathogens along with their antimicrobial susceptibility pattern in patients presenting to a pediatric tertiary care center in the Korangi district of Karachi, Pakistan.
The study employed an observational cross-sectional design.
The study was conducted at the Microbiology laboratory of Sindh Institute of Child Health and Neonatology, Karachi, Pakistan from 1st January to 15th August 2023. Urine samples of patients 1 to 16 years of age were collected via midstream clean catch method and of patients from birth up to 1 year were collected in urine collection bags. The samples were cultured on Cystine Lactose Electrolyte Deficient (CLED) agar and antibiotic susceptibility testing was performed using the Kirby-Bauer Disc Diffusion method.
A total of 457 urine samples were collected, of which 90 (19.7%) were positive for significant uropathogens. With a mean age of 4.6 years, majority of the culture-positive patients were female (n = 72; 80%). Enterobacterales were the most frequently isolated (n = 88; 95.6%), of which
was the most common (73.9%; n = 68).
(n = 7; 7.6%),
(n = 6; 6.5%),
(n = 4; 4.3%),
(n = 2; 2.2%),
(n = 2; 2.2%), and
(n = 1; 1.1%) were among the other Enterobacterales isolated. Meropenem and imipenem were the most effective in isolates from Enterobacterales (n = 88) followed by amikacin (n = 84), ciprofloxacin (n = 75), and piperacillin-tazobactam (n = 70). Ceftriaxone and cefixime exhibited moderate susceptibility (n = 69 and 52) whereas, amoxicillin-clavulanate was the least susceptible (n = 3).
We report high frequency of UTI in our pediatric population with uropathogens and associated antimicrobial susceptibility pattern confirming to the existing trends of pediatric UTIs in Pakistan. In addition to valuable insights for treating patients under similar conditions, our study serves as a catalyst for further multi-center research in this area. |
doi_str_mv | 10.1177/11795565241254321 |
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The study aims to evaluate the frequency of UTI and distribution of uropathogens along with their antimicrobial susceptibility pattern in patients presenting to a pediatric tertiary care center in the Korangi district of Karachi, Pakistan.
The study employed an observational cross-sectional design.
The study was conducted at the Microbiology laboratory of Sindh Institute of Child Health and Neonatology, Karachi, Pakistan from 1st January to 15th August 2023. Urine samples of patients 1 to 16 years of age were collected via midstream clean catch method and of patients from birth up to 1 year were collected in urine collection bags. The samples were cultured on Cystine Lactose Electrolyte Deficient (CLED) agar and antibiotic susceptibility testing was performed using the Kirby-Bauer Disc Diffusion method.
A total of 457 urine samples were collected, of which 90 (19.7%) were positive for significant uropathogens. With a mean age of 4.6 years, majority of the culture-positive patients were female (n = 72; 80%). Enterobacterales were the most frequently isolated (n = 88; 95.6%), of which
was the most common (73.9%; n = 68).
(n = 7; 7.6%),
(n = 6; 6.5%),
(n = 4; 4.3%),
(n = 2; 2.2%),
(n = 2; 2.2%), and
(n = 1; 1.1%) were among the other Enterobacterales isolated. Meropenem and imipenem were the most effective in isolates from Enterobacterales (n = 88) followed by amikacin (n = 84), ciprofloxacin (n = 75), and piperacillin-tazobactam (n = 70). Ceftriaxone and cefixime exhibited moderate susceptibility (n = 69 and 52) whereas, amoxicillin-clavulanate was the least susceptible (n = 3).
We report high frequency of UTI in our pediatric population with uropathogens and associated antimicrobial susceptibility pattern confirming to the existing trends of pediatric UTIs in Pakistan. In addition to valuable insights for treating patients under similar conditions, our study serves as a catalyst for further multi-center research in this area.</description><identifier>ISSN: 1179-5565</identifier><identifier>EISSN: 1179-5565</identifier><identifier>DOI: 10.1177/11795565241254321</identifier><identifier>PMID: 39044848</identifier><language>eng</language><publisher>United States: SAGE Publications</publisher><ispartof>Clinical medicine insights. Pediatrics, 2024-01, Vol.18, p.11795565241254321</ispartof><rights>The Author(s) 2024.</rights><rights>The Author(s) 2024 2024 SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c282t-b72507f27c0c6ec33f641cda3f028072122e211107713d58f5e75dabf8febb413</cites><orcidid>0009-0004-2726-277X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11265240/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11265240/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,37013,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39044848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, Moiz Ahmed</creatorcontrib><creatorcontrib>Shakeel, Nosheen</creatorcontrib><title>Pediatric Uropathogens and their Antimicrobial Susceptibility Pattern: Experience from an Impoverished District of Karachi, Pakistan</title><title>Clinical medicine insights. Pediatrics</title><addtitle>Clin Med Insights Pediatr</addtitle><description>Urinary tract infection (UTI) is the most common infection of the pediatric age group. Several factors linked to higher prevalence include poor personal hygiene, improper sanitation, lower socioeconomic status, and malnourishment. In addition to having a worse quality of life, the 1.8 million children who live in Karachi's Korangi district are routinely exposed to such factors.
The study aims to evaluate the frequency of UTI and distribution of uropathogens along with their antimicrobial susceptibility pattern in patients presenting to a pediatric tertiary care center in the Korangi district of Karachi, Pakistan.
The study employed an observational cross-sectional design.
The study was conducted at the Microbiology laboratory of Sindh Institute of Child Health and Neonatology, Karachi, Pakistan from 1st January to 15th August 2023. Urine samples of patients 1 to 16 years of age were collected via midstream clean catch method and of patients from birth up to 1 year were collected in urine collection bags. The samples were cultured on Cystine Lactose Electrolyte Deficient (CLED) agar and antibiotic susceptibility testing was performed using the Kirby-Bauer Disc Diffusion method.
A total of 457 urine samples were collected, of which 90 (19.7%) were positive for significant uropathogens. With a mean age of 4.6 years, majority of the culture-positive patients were female (n = 72; 80%). Enterobacterales were the most frequently isolated (n = 88; 95.6%), of which
was the most common (73.9%; n = 68).
(n = 7; 7.6%),
(n = 6; 6.5%),
(n = 4; 4.3%),
(n = 2; 2.2%),
(n = 2; 2.2%), and
(n = 1; 1.1%) were among the other Enterobacterales isolated. Meropenem and imipenem were the most effective in isolates from Enterobacterales (n = 88) followed by amikacin (n = 84), ciprofloxacin (n = 75), and piperacillin-tazobactam (n = 70). Ceftriaxone and cefixime exhibited moderate susceptibility (n = 69 and 52) whereas, amoxicillin-clavulanate was the least susceptible (n = 3).
We report high frequency of UTI in our pediatric population with uropathogens and associated antimicrobial susceptibility pattern confirming to the existing trends of pediatric UTIs in Pakistan. In addition to valuable insights for treating patients under similar conditions, our study serves as a catalyst for further multi-center research in this area.</description><issn>1179-5565</issn><issn>1179-5565</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNplUUFPHSEYJE1NNdYf0EvDsYc-ywfLY18vjbFqTU1q0nomLPvh0u7CFnim3v3hZaM1NnIAMszMR2YIeQPsEECpD3XbSLmWvAEuG8HhBdlbsNUCvnxy3yUHOf9kdTUbIeT6FdkVG9Y0bdPukbtL7L0pyVt6leJsyhCvMWRqQk_LgD7Ro1D85G2KnTcj_b7NFufiOz_6cksvTSmYwkd68mfG5DFYpC7Fqerp-TTHmwrmAXv62edlSKHR0a8mGTv491X9q8ImvCY7zowZDx7OfXJ1evLj-Mvq4tvZ-fHRxcrylpdVp7hkynFlmV2jFcKtG7C9EY7xlikOnCMHAKYUiF62TqKSvelc67DrGhD75NO977ztJuwthpLMqOfkJ5NudTRe__8S_KCv440G4EvQrDq8e3BI8fcWc9GTr4GMowkYt1kL1lYW8A2vVLin1uhyTuge5wDTS4P6WYNV8_bpBx8V__oSfwE-Q5j6</recordid><startdate>20240101</startdate><enddate>20240101</enddate><creator>Khan, Moiz Ahmed</creator><creator>Shakeel, Nosheen</creator><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0009-0004-2726-277X</orcidid></search><sort><creationdate>20240101</creationdate><title>Pediatric Uropathogens and their Antimicrobial Susceptibility Pattern: Experience from an Impoverished District of Karachi, Pakistan</title><author>Khan, Moiz Ahmed ; Shakeel, Nosheen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-b72507f27c0c6ec33f641cda3f028072122e211107713d58f5e75dabf8febb413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Moiz Ahmed</creatorcontrib><creatorcontrib>Shakeel, Nosheen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Clinical medicine insights. Pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Moiz Ahmed</au><au>Shakeel, Nosheen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pediatric Uropathogens and their Antimicrobial Susceptibility Pattern: Experience from an Impoverished District of Karachi, Pakistan</atitle><jtitle>Clinical medicine insights. Pediatrics</jtitle><addtitle>Clin Med Insights Pediatr</addtitle><date>2024-01-01</date><risdate>2024</risdate><volume>18</volume><spage>11795565241254321</spage><pages>11795565241254321-</pages><issn>1179-5565</issn><eissn>1179-5565</eissn><abstract>Urinary tract infection (UTI) is the most common infection of the pediatric age group. Several factors linked to higher prevalence include poor personal hygiene, improper sanitation, lower socioeconomic status, and malnourishment. In addition to having a worse quality of life, the 1.8 million children who live in Karachi's Korangi district are routinely exposed to such factors.
The study aims to evaluate the frequency of UTI and distribution of uropathogens along with their antimicrobial susceptibility pattern in patients presenting to a pediatric tertiary care center in the Korangi district of Karachi, Pakistan.
The study employed an observational cross-sectional design.
The study was conducted at the Microbiology laboratory of Sindh Institute of Child Health and Neonatology, Karachi, Pakistan from 1st January to 15th August 2023. Urine samples of patients 1 to 16 years of age were collected via midstream clean catch method and of patients from birth up to 1 year were collected in urine collection bags. The samples were cultured on Cystine Lactose Electrolyte Deficient (CLED) agar and antibiotic susceptibility testing was performed using the Kirby-Bauer Disc Diffusion method.
A total of 457 urine samples were collected, of which 90 (19.7%) were positive for significant uropathogens. With a mean age of 4.6 years, majority of the culture-positive patients were female (n = 72; 80%). Enterobacterales were the most frequently isolated (n = 88; 95.6%), of which
was the most common (73.9%; n = 68).
(n = 7; 7.6%),
(n = 6; 6.5%),
(n = 4; 4.3%),
(n = 2; 2.2%),
(n = 2; 2.2%), and
(n = 1; 1.1%) were among the other Enterobacterales isolated. Meropenem and imipenem were the most effective in isolates from Enterobacterales (n = 88) followed by amikacin (n = 84), ciprofloxacin (n = 75), and piperacillin-tazobactam (n = 70). Ceftriaxone and cefixime exhibited moderate susceptibility (n = 69 and 52) whereas, amoxicillin-clavulanate was the least susceptible (n = 3).
We report high frequency of UTI in our pediatric population with uropathogens and associated antimicrobial susceptibility pattern confirming to the existing trends of pediatric UTIs in Pakistan. In addition to valuable insights for treating patients under similar conditions, our study serves as a catalyst for further multi-center research in this area.</abstract><cop>United States</cop><pub>SAGE Publications</pub><pmid>39044848</pmid><doi>10.1177/11795565241254321</doi><orcidid>https://orcid.org/0009-0004-2726-277X</orcidid><oa>free_for_read</oa></addata></record> |
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title | Pediatric Uropathogens and their Antimicrobial Susceptibility Pattern: Experience from an Impoverished District of Karachi, Pakistan |
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