Chemical fingerprinting, antimicrobial, antioxidant, anti‐inflammatory, and anticancer potential of greenly synthesized silver nanoparticles from pistachio (Pistacia vera) nuts and senna (Cassia angustifolia Vahl.) leaves

• Published in: Food science & nutrition 2024-07, Vol.12 (7), p.4989-5006
• Main Authors: Irshad, Saba, Iftikhar, Sabahat, Riaz, Muhammad, Mahmood, Azra, Mushtaq, Afaq, Saleem, Yasar, Shamim, Rahat, Akter, Quzi Sharmin
• Format: Article
• Language: English
• Subjects: Analgesics; anticancer; Antiinfectives and antibacterials; Antioxidants; anti‐inflammatory; Assaying; Bioactive compounds; Biocompatibility; Biological activity; Biological effects; Blood pressure; Cancer; Carotenoids; Cassia angustifolia; Chemical fingerprinting; Chemical synthesis; Denaturation; Ethanol; Fatty acids; Fingerprinting; Flavonoids; Fourier transforms; Herbal medicine; Inflammation; Infrared spectroscopy; Leaves; Nanomaterials; Nanoparticles; Nanostructure; Nuts; Original; Oxidative stress; Pharmacology; Phytochemicals; Pistacia vera; Plant extracts; Polyphenols; Scanning electron microscopy; Silver; silver nanoparticles
• ISSN: 2048-7177; 2048-7177
• DOI: 10.1002/fsn3.4148

There is a growing interest in standardizing the biocompatible, cost‐effective, and eco‐friendly manufacturing techniques for metallic nanostructures due to their widespread applications in the industrial and medical sectors. In recent decades, green synthesis has been proven as the most suitable technique for synthesizing metal nanoparticles. The present research study investigates the use of Cassia angustifolia (senna) leaves and Pistacia vera (Pistachio) nuts to prepare crude aqueous extracts, ethanolic extracts, and biogenic silver nanoparticles (AgNPs). The prepared aqueous extracts were used as reducing, stabilizing, and capping agents for the production of silver nanoparticles. These AgNPs were characterized by scanning electron microscopy (SEM), Fourier‐transform infrared spectroscopy (FTIR), and ultraviolet–visible (UV–Vis) spectroscopy. The outcomes validated the formation of stable AgNPs with bioactive functional components. In vitro antibacterial, anticancer, anti‐inflammatory, and antioxidant potentials were assessed by Kirby–Bauer disk diffusion test, MIC test, MBC test, MTT assay, BSA denaturation inhibition assay, and DPPH antioxidant assay, respectively. Results confirmed that the tested plant extract possesses a variety of bioactive compounds with various biological activities and is therapeutically effective. These findings verified that C. angustifolia and P. vera are promising bioresources for the synthesis of therapeutic extracts and nanostructures with commendable therapeutic potency. In recent decades, green synthesis has been attested as the most suitable technique for synthesizing metal nanoparticles. C. angustifolia and P. vera extract possess a variety of bioactive compounds with various biological activities and are therapeutically effective. C. angustifolia and P. vera are promising bioresources for the synthesis of therapeutic extracts and nanostructures with commendable therapeutic potency.