Biomarkers of Orthodontic Patients After Use of 1% Brazilian Red Propolis Toothpaste: A Randomized Clinical Study

AbstractAim:To evaluate the salivary biomarkers and plaque index after a treatment with a propolis-contained toothpaste.Materials and Methods:This is a longitudinal, randomized, double-blind study where 76 participants were randomized into two groups: Group I: Fluoridated Red Propolis toothpaste; Gr...

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Published in:Journal of International Society of Preventive and Community Dentistry 2024-05, Vol.14 (3), p.218-224
Main Authors: do Amaral Silva, Mônica, Valadas, Lídia Audrey Rocha, Lopes de Oliveira, Guilherme Antônio, Rodrigues Neto, Edilson Martins, de Alencar Júnior, Emmanuel Arraes, Dantas Lobo, Patricia Leal, Dantas, Thereza Cristina Farias Botelho, Bandeira, Mary Anne Medeiros, de França Fonteles, Marta Maria, Baptista, Gandhi Radis
Format: Article
Language:English
Subjects:
Biomarkers
Circadian rhythms
Clinical trials
Dentifrices
Hygiene
Interleukin 10
Oral hygiene
Original
Orthodontics
pH effects
Plaque index
Propolis
Saliva
Statistical analysis
Toothpaste
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Summary:AbstractAim:To evaluate the salivary biomarkers and plaque index after a treatment with a propolis-contained toothpaste.Materials and Methods:This is a longitudinal, randomized, double-blind study where 76 participants were randomized into two groups: Group I: Fluoridated Red Propolis toothpaste; Group II: Fluoridated toothpaste. The participants were selected in a municipality without fluoridated public water. All participants received standardized oral hygiene instructions from the same instructor for 3 daily brushings (after breakfast, after lunch, and before bed) for a period of 2 min; Saliva samples were collected before (D0) and after 28 days (D28) of treatment for analysis of pH and total protein, amylase, and IL-10. Saliva was collected in the initial consultation and on return, totaling two collections. All samples were collected under the same conditions, by the same operator and between 9:00 am and 11:00 am in order to minimize the influence of circadian rhythm on salivary flow.Results:On D0 and D28, the various treatments had no effect on total salivary proteins (G1: P = 0.0746; G2: P = 0.2144), and the pH stayed about the same. Additionally, there was no change in the amylase activity in G1 (P = 0.1877) or G2 (P = 0.4674). Significant decreases in G1 (P < 0.0001) and G2 (P = 0.03) were observed with IL-10. There was no statistically significant difference in the salivary flow between the BRP toothpaste-treated group (P = 0.172) and the commercial fluoridated toothpaste-treated group (P = 0.329). Compared to G2 (P = 0.03), G1 showed a superior decline in the plaque index (P =
ISSN:2231-0762
2250-1002
DOI:10.4103/jispcd.jispcd_120_23