The GG genotype of rs743572 in CYP17A1 gene regulating the decrease of T/E ratio can be an independent risk factor for MetS-BPH: a retrospective cohort study

• Published in: World journal of urology 2024-07, Vol.42 (1), p.439, Article 439
• Main Authors: Chen, Congcong, Pan, Ningrui, Chen, Zongping, Gou, Chengren, He, Xu, Wang, Min, Chen, Bo, Zhou, Zidong, Ren, Qixu, Zhong, Youzhuang, Xiang, You, Zhao, Sicong, Yan, Yong, Song, Tao
• Format: Article
• Language: English
• Subjects: 17β-Estradiol; Aged; Aged, 80 and over; Cohort Studies; Estradiol - blood; Genotype; Genotype & phenotype; Genotypes; Humans; Male; Medicine; Medicine & Public Health; Middle Aged; Nephrology; Oncology; Polymorphism, Single Nucleotide; Prostatic Hyperplasia - genetics; Retrospective Studies; Risk Factors; Single-nucleotide polymorphism; Steroid 17-alpha-Hydroxylase - genetics; Testosterone; Testosterone - blood; Urology
• ISSN: 1433-8726; 0724-4983; 1433-8726
• DOI: 10.1007/s00345-024-05138-3

Purpose To confirm if the CYP17A1 gene regulates the ratio of T/E leading to MetS-BPH. Methods 824 men, aged 47–88 years, were recruited into this study through consecutive routine physical examination programs and long-term outpatient screening. Several parameters, including SNPs of CYP17A1 gene, total testosterone, estradiol, and the ratio of total testosterone to estradiol (T/E) were obtained for each participant. Based on the diagnosis of BPH, MetS, and MetS-BPH, the participants were divided into BPH and non-BPH groups, MetS and non-MetS groups, and MetS-BPH and non-MetS-BPH groups. Values of the obtained parameters were evaluated using one-way analysis of variance, Student’s t-test, Chi-squared test, and logistic regression analysis. Results SNPs of the CYP17A1 gene, including the rs743572 genotypes (GG, GA, and AA), rs3781287 genotypes (GG, GT, TT), and rs4919686 genotypes (CC, CA, and AA), were present in every group. Only the GG genotype of rs743572 was independently associated with BPH (OR = 5.868, 95% CI: 3.363–7.974, P